{"doi":"10.1039/d5dt00082c","title":"The binuclear copper state of peptidylglycine monooxygenase visualized through a selenium-substituted peptidyl-homocysteine complex","abstract":", 5074-5080). In the ascorbate-reduced Cu(I) state of PHM, EXAFS measurements at both the Se and Cu absorption edges provide a unique signature of a bridging mode of binding, with Se-Cu site occupancy (1.8) measured from the Se-EXAFS simulating to twice that of the Cu-Se site occupancy (0.85) measured at the Cu edge. The ability of the hSeCys entity to induce a binuclear state is further emphasized by the XAS of the selenomethionyl peptide complex, where no such bridging chemistry is observed. The properties of the binuclear PHM derivative are of interest due to their unique chemical signatures, as well as providing the basis for a completely new mechanistic paradigm for PHM and its monooxygenase congeners.","journal":"Dalton Transactions","year":2025,"id":538771,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":328495,"name":"Katherine W. Rush","orcid":"0000-0001-6842-9055","position":1,"is_corresponding":false},{"id":1358841,"name":"Karsten Eastman","orcid":null,"position":2,"is_corresponding":false},{"id":675304,"name":"Vahe Bandarian","orcid":"0000-0003-2302-0277","position":3,"is_corresponding":false},{"id":564520,"name":"Ninian J. Blackburn","orcid":"0000-0002-9755-7838","position":4,"is_corresponding":false},{"id":905490,"name":"Evan F. Welch","orcid":null,"position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T02:52:25.799399Z","pmid":"39981625","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}