{"doi":"10.1039/d4ra06682k","title":"Ionic resorcinarenes as drug solubilization agents in water","abstract":"H NMR measurements of resorcinarene-drug mixtures confirmed interactions with shift changes ranging from -0.20 to 0.81 ppm. Binding affinities quantified through ITC experiments ranged between 0.54 and 211 mM, signifying interactions between resorcinarenes and drug compounds necessary for the solubility of the drugs. Cytotoxicity studies suggest that resorcinarenes alone, or complexed with any of the drug compounds, do not exert cytotoxicity in mammalian cells HEK-293 up to 200 μM. We herein propose a set of hydrophilic resorcinarene macrocycles as potential drug solubilizers.","journal":"RSC Advances","year":2024,"id":462395,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1291826,"name":"Kwaku Twum","orcid":"0000-0001-5390-0609","position":1,"is_corresponding":false},{"id":1291827,"name":"B. Manfredi","orcid":"0000-0002-6159-2674","position":2,"is_corresponding":false},{"id":1292237,"name":"Mariana Fatohi","orcid":null,"position":3,"is_corresponding":false},{"id":1291828,"name":"Yvonne Bessem Ojong","orcid":"0000-0002-1208-5051","position":4,"is_corresponding":false},{"id":1292238,"name":"Valance Washington","orcid":null,"position":5,"is_corresponding":false},{"id":1291829,"name":"Ngong Kodiah Beyeh","orcid":"0000-0003-3935-1812","position":6,"is_corresponding":false},{"id":1291825,"name":"Frank Boateng Osei","orcid":"0000-0003-0223-7602","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T02:04:20.631898Z","pmid":"39469002","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}