{"doi":"10.1039/d4ra04194a","title":"Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids","abstract":". 3D tissue cultures have opened new avenues for exploring development and disease modeling. However, many physiological conditions, including signaling gradients in 3D cultures, have not yet been easily achieved. Here, we introduce brain organoid-on-a-chip platforms that generate signaling gradients that in turn enable the induction of topographic forebrain organoids. This creates a more continuous spectrum of brain regions and provides a more complete mimic of the human brain for evaluating neurodevelopment and disease in unprecedented detail.","journal":"RSC Advances","year":2025,"id":517006,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1169914,"name":"Hajime Ozaki","orcid":"0009-0000-5940-2096","position":1,"is_corresponding":false},{"id":1170407,"name":"Ango Morikawa","orcid":null,"position":2,"is_corresponding":false},{"id":1170408,"name":"Kaori Shiraiwa","orcid":null,"position":3,"is_corresponding":false},{"id":1170409,"name":"Andy Prosvey Pin","orcid":null,"position":4,"is_corresponding":false},{"id":1170410,"name":"Aya Galal Salem","orcid":null,"position":5,"is_corresponding":false},{"id":1170411,"name":"Kenneth Akady Phommahasay","orcid":null,"position":6,"is_corresponding":false},{"id":1170412,"name":"Bret Kiyoshi Sugita","orcid":null,"position":7,"is_corresponding":false},{"id":1169915,"name":"Christine Hein Vu","orcid":"0000-0001-8068-9183","position":8,"is_corresponding":false},{"id":1170413,"name":"Saba Mamoun Hammad","orcid":null,"position":9,"is_corresponding":false},{"id":1169916,"name":"Ken‐ichiro Kamei","orcid":"0000-0003-2948-3264","position":10,"is_corresponding":false},{"id":756389,"name":"Momoko Watanabe","orcid":"0000-0001-5014-2849","position":11,"is_corresponding":false},{"id":848330,"name":"Yuan‐Chen Tsai","orcid":"0000-0001-5250-0646","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:48:54.768083Z","pmid":"39911547","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}