{"doi":"10.1039/d4md00320a","title":"A novel hydrophobic tag leads to the efficient degradation of programmed death-ligand 1","abstract":", which indicated that Z2d/Z3d degraded PD-L1 through the proteasome pathway. Moreover, the molecular modeling results indicated that the HyT group of Z2d or Z3d extended the surface of the protein to mimic the misfold. Importantly, our work also identified a novel HyT, which could be applied to develop the HyTTD for other target proteins.","journal":"RSC Medicinal Chemistry","year":2024,"id":445007,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1261422,"name":"Yongli Xie","orcid":null,"position":1,"is_corresponding":false},{"id":765414,"name":"Jiantao Zhang","orcid":"0000-0002-2875-9743","position":2,"is_corresponding":false},{"id":1260905,"name":"Huirong Chen","orcid":"0000-0003-3091-1668","position":3,"is_corresponding":false},{"id":373581,"name":"Yan Zou","orcid":"0000-0002-4743-4995","position":4,"is_corresponding":false},{"id":1260906,"name":"Shan Cen","orcid":"0000-0003-3358-0411","position":5,"is_corresponding":false},{"id":1260907,"name":"Jinming Zhou","orcid":"0000-0003-1610-5061","position":6,"is_corresponding":false},{"id":1261421,"name":"Jieke Gao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:01:42.089235Z","pmid":"39309365","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}