{"doi":"10.1039/d4fo06086e","title":"Comment on “The quercetin metabolite 4-methylcatechol causes vasodilation <i>via</i> voltage-gated potassium (Kv) channels” by Patrícia Dias, Rudy Salam, Jana Pourová, Marie Vopršalová, Lukáš Konečný, Eduard Jirkovský, Jurjen Duintjer Tebbens and Přemysl Mladěnka, <i>Food &amp; Function</i> , 2024, <b>15</b> , 11047","abstract":"reverse docking confirmed that 4-MC [4-methylcatechol] binds to Kv7.4\" and that \"4-MC exerts vasorelaxation by opening Kv channels with the involvement of Kv7.4\". Here, we tested their conclusions using heterologous expression experiments, an important step in target validation, and found that Kv7.4 is in fact insensitive to 4-MC.","journal":"Food & Function","year":2025,"id":543259,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1432963,"name":"Hạnh Thị Thuý Nguyễn","orcid":"0000-0002-9108-905X","position":1,"is_corresponding":false},{"id":350953,"name":"Geoffrey W. Abbott","orcid":"0000-0003-4552-496X","position":2,"is_corresponding":false},{"id":350952,"name":"Rían W. Manville","orcid":"0000-0002-0057-3541","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:53:04.088079Z","pmid":"40094416","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}