{"doi":"10.1039/d4dt01663g","title":"Stoichiometry effect on the structure, coordination and anticancer activity of gold( <scp>i</scp> / <scp>iii</scp> ) bisphosphine complexes","abstract":"P NMR showed characteristic singlet peak at ∼22 ppm for the Au(I) complexes and ∼57 ppm for the Au(III) complexes. The structure of the Au(III) complexes was further confirmed by X-ray crystallography as a 5-coordinate Au(III) complex. Although both Au(I) and Au(III) complexes showed promising anticancer activity in MDA-MB-231 (breast cancer) and BT-333 (glioblastoma) cancer cell lines and inhibited maximal mitochondria respiration in MDA-MB-231 cells, the Au(III) complexes further induce ROS accumulation and facilitate depolarization of the mitochondria membrane potential in MDA-MB-231 cells. Taken together, the synthetic approach provides a way to elucidate the effect of Au(I)/Au(III) oxidation states on structure, activity, and potential mechanism with respect to the same ligand.","journal":"Dalton Transactions","year":2024,"id":458969,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1285780,"name":"Justin D. Holmes","orcid":"0000-0001-5087-8936","position":1,"is_corresponding":false},{"id":1261241,"name":"Oluwatosin A. Obisesan","orcid":"0000-0001-6608-6765","position":2,"is_corresponding":false},{"id":324224,"name":"Sean Parkin","orcid":"0000-0001-5777-3918","position":3,"is_corresponding":false},{"id":324225,"name":"Samuel G. Awuah","orcid":"0000-0003-4947-7283","position":4,"is_corresponding":false},{"id":424810,"name":"Adedamola S. Arojojoye","orcid":"0000-0003-3076-264X","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:03:55.280882Z","pmid":"39688257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}