{"doi":"10.1039/d4cc04165h","title":"Fluorine-18 incorporation and radiometal coordination in macropa ligands for PET imaging and targeted alpha therapy","abstract":"the functionalization of the ligand with the diagnostic radionuclide fluorine-18. An analogue of macropa, an 18-membered macrocyclic chelator with high affinity for alpha therapeutic radiometals, was synthesized and its complexation properties with metal ions were determined. The new macropa-F ligand was used for quantitative radiometal complexation with lead-203 and bismuth-207, as surrogates for their alpha-emitting radioisotopes. As a diagnostic partner, a radiofluorinated macropa ligand was used for quantitative bismuth(III) and lead(II) complexation. All fluorine-18 and radiometal complexes are highly stable in human serum over several days. This study presents a new proof-of-principle approach for developing theranostic agents based on alpha-emitting radionuclides and fluorine-18.","journal":"Chemical Communications","year":2024,"id":466473,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":904075,"name":"Yang Sun","orcid":"0000-0001-6728-4923","position":1,"is_corresponding":false},{"id":1271032,"name":"Kevin K. Lee","orcid":"0000-0002-1510-0237","position":2,"is_corresponding":false},{"id":415533,"name":"Samantha N. MacMillan","orcid":"0000-0001-6516-1823","position":3,"is_corresponding":false},{"id":353533,"name":"Pedro Brugarolas","orcid":"0000-0002-7455-2743","position":4,"is_corresponding":false},{"id":327012,"name":"Justin J. Wilson","orcid":"0000-0002-4086-7982","position":5,"is_corresponding":false},{"id":1271033,"name":"Thines Kanagasundaram","orcid":"0000-0001-8265-8591","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:05:06.743102Z","pmid":"39352495","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}