{"doi":"10.1039/d3sm01009k","title":"Injectable liposome-containing click hydrogel microparticles for release of macromolecular cargos","abstract":"droplet-based-microfluidics we have established a method for producing click poly-(ethylene)-glycol (PEG)-based microgels with or without chemically crosslinked liposomes (lipo-microgels) through the Michael-type addition reaction between thiol and either vinyl-sulfone or maleimide groups. Unifom spherical microgels and lipo-microgels were generated with sizes of 74 ± 16 μm and 82 ± 25 μm, respectively, suggesting injectability that was further supported by rheological analyses. Super-resolution confocal microscopy was used to further verify the presence of liposomes within the lipo-microgels and determine their distribution. Atomic force microscopy (AFM) was conducted to compare the mechanical properties and network architecture of bulk hydrogels, microgels, and lipo-microgels. Further, encapsulation and release of model cargo (FITC-Dextran 5 kDa) and protein (equine myoglobin) showed sustained release for up to 3 weeks and retention of protein composition and secondary structure, indicating their ability to both protect and release cargos of interest.","journal":"Soft Matter","year":2024,"id":448185,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":516478,"name":"Paige J. LeValley","orcid":"0000-0002-5716-6031","position":1,"is_corresponding":false},{"id":476470,"name":"Lina Pradhan","orcid":"0000-0001-9984-5318","position":2,"is_corresponding":false},{"id":976621,"name":"Amanda L. Parsons","orcid":"0009-0002-2956-0960","position":3,"is_corresponding":false},{"id":491637,"name":"John Oakey","orcid":"0000-0003-1023-1964","position":4,"is_corresponding":false},{"id":159157,"name":"Mathew Abraham","orcid":null,"position":5,"is_corresponding":false},{"id":1266826,"name":"Suzanne M. D’Addio","orcid":"0000-0002-6464-0758","position":6,"is_corresponding":false},{"id":417699,"name":"April M. Kloxin","orcid":"0000-0002-4594-2953","position":7,"is_corresponding":false},{"id":1266827,"name":"Yingkai Liang","orcid":"0000-0002-8981-7951","position":8,"is_corresponding":false},{"id":307397,"name":"Kristi L. Kiick","orcid":"0000-0001-8587-0301","position":9,"is_corresponding":false},{"id":479447,"name":"Luisa L. Palmese","orcid":"0000-0002-8289-9261","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"38288734","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}