{"doi":"10.1039/d3sc05185d","title":"A β-barrel-like tetramer formed by a β-hairpin derived from Aβ","abstract":"in one of these three alignments and investigated their solution-phase assembly and folding. These assays reveal the formation of tetramers and octamers that are stabilized by intermolecular hydrogen bonding interactions between Aβ residues 12-14 and 38-40 as part of an extended β-hairpin conformation. X-ray crystallographic studies of one peptide from this series reveal the formation of β-barrel-like tetramers and octamers that are stabilized by edge-to-edge hydrogen bonding and hydrophobic packing. Dye-leakage and caspase 3/7 activation assays using tetramer and octamer forming peptides from this series reveal membrane-damaging and apoptotic properties. A molecular dynamics simulation of the β-barrel-like tetramer embedded in a lipid bilayer shows membrane disruption and water permeation. The tetramers and octamers described herein provide additional models of how Aβ may assemble into oligomers and supports the hypothesis that β-hairpin alignment and topology may contribute directly to oligomer heterogeneity.","journal":"Chemical Science","year":2023,"id":348794,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":917469,"name":"Chelsea R. Jones","orcid":"0000-0002-8347-6885","position":1,"is_corresponding":false},{"id":797109,"name":"Gretchen Guaglianone","orcid":"0000-0002-5189-2550","position":2,"is_corresponding":false},{"id":678465,"name":"Adam G. Kreutzer","orcid":"0000-0002-9724-6298","position":3,"is_corresponding":false},{"id":445430,"name":"J. Alfredo Freites","orcid":"0000-0001-5842-7443","position":4,"is_corresponding":false},{"id":735333,"name":"Michał Wierzbicki","orcid":"0000-0002-9217-634X","position":5,"is_corresponding":false},{"id":168285,"name":"James S. Nowick","orcid":"0000-0002-2273-1029","position":6,"is_corresponding":false},{"id":686631,"name":"Tuan D. Samdin","orcid":"0000-0003-3516-9175","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:12:10.335697Z","pmid":"38131075","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}