{"doi":"10.1039/d3sc00955f","title":"Transcription activation by the resistance protein AlbA as a tool to evaluate derivatives of the antibiotic albicidin","abstract":", we designed a transcription reporter assay. In addition, by screening shorter albicidin fragments, as well as various DNA-binders and gyrase poisons, we were able to gain insights into the AlbA target spectrum. We analysed the effect of mutations in the binding domain of AlbA on albicidin sequestration and transcription activation, and found that the signal transduction mechanism is complex but can be evaded. Further demonstrating AlbA's high level of specificity, we find clues for the logical design of molecules capable of avoiding the resistance mechanism.","journal":"Chemical Science","year":2023,"id":372583,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1133619,"name":"Lida Rostock","orcid":null,"position":1,"is_corresponding":false},{"id":1133193,"name":"Jonas Barsig","orcid":"0009-0009-6787-6967","position":2,"is_corresponding":false},{"id":1133620,"name":"Theresa Tabarelli","orcid":null,"position":3,"is_corresponding":false},{"id":1133194,"name":"Kay Hommernick","orcid":"0000-0001-5538-2382","position":4,"is_corresponding":false},{"id":1133621,"name":"Marcel Kulike","orcid":null,"position":5,"is_corresponding":false},{"id":1133622,"name":"Tobias Eulberg","orcid":null,"position":6,"is_corresponding":false},{"id":1133195,"name":"Maria Seidel","orcid":"0000-0001-8466-3378","position":7,"is_corresponding":false},{"id":1133623,"name":"Iraj Behroz","orcid":null,"position":8,"is_corresponding":false},{"id":1133196,"name":"Leonardo Kleebauer","orcid":"0000-0002-7414-2293","position":9,"is_corresponding":false},{"id":1133624,"name":"S. Gratz","orcid":null,"position":10,"is_corresponding":false},{"id":1133197,"name":"Andi Mainz","orcid":"0000-0003-3428-864X","position":11,"is_corresponding":false},{"id":630686,"name":"Roderich D. Süßmuth","orcid":"0000-0001-7027-2069","position":12,"is_corresponding":false},{"id":906292,"name":"Simone Kosol","orcid":"0000-0001-7913-4818","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:15:58.101083Z","pmid":"37206387","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}