{"doi":"10.1039/d3ob00123g","title":"A structure activity relationship study of 3,4′-dimethoxyflavone for ArlRS inhibition in <i>Staphylococcus aureus</i>","abstract":". We recently disclosed 3,4'-dimethoxyflavone as a selective ArlRS inhibitor. In this study we explore the structure-activity relationship (SAR) of the flavone scaffold for ArlRS inhibition and identify several compounds with increased activity compared to the parent. Additionally, we identify a compound that suppresses oxacillin resistance in MRSA, and begin to probe the mechanism of action behind this activity.","journal":"Organic & Biomolecular Chemistry","year":2023,"id":365370,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1121263,"name":"Patrick M. O'Conner","orcid":null,"position":1,"is_corresponding":false},{"id":230750,"name":"Jakub Kwieciński","orcid":"0000-0001-9472-2896","position":2,"is_corresponding":false},{"id":518355,"name":"Orry M. Marciano","orcid":null,"position":3,"is_corresponding":false},{"id":1121264,"name":"Angelica Nunag","orcid":null,"position":4,"is_corresponding":false},{"id":1121265,"name":"Andrew T. Gutierrez","orcid":null,"position":5,"is_corresponding":false},{"id":517532,"name":"Roberta J. Melander","orcid":"0000-0002-3548-3351","position":6,"is_corresponding":false},{"id":230751,"name":"Alexander R. Horswill","orcid":"0000-0002-5568-0096","position":7,"is_corresponding":false},{"id":258371,"name":"Christian Melander","orcid":"0000-0001-8271-4696","position":8,"is_corresponding":false},{"id":414931,"name":"Alexander W. Weig","orcid":null,"position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:14:46.760245Z","pmid":"37013457","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}