{"doi":"10.1039/d3nh00096f","title":"Super-resolution imaging of linearized chromatin in tunable nanochannels","abstract":"is analyzed by multi-color imaging of total DNA, newly synthesized DNA, and newly synthesized histone H3. Our analysis reveals a relatively even distribution of newly synthesized H3 across two halves of the rDNA chromatin with palindromic symmetry, supporting dispersive nucleosome segregation. As a proof-of-concept study, our work achieves super-resolution imaging of native chromatin fibers linearized and immobilized in tunable nanochannels. It opens up a new avenue for collecting long-range and high-resolution epigenetic information as well as genetic information.","journal":"Nanoscale Horizons","year":2023,"id":381930,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9509,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":981127,"name":"Joyce Han-Ching Chiu","orcid":null,"position":1,"is_corresponding":false},{"id":980761,"name":"Nicholas J. Ginga","orcid":"0000-0003-4087-2447","position":2,"is_corresponding":false},{"id":644093,"name":"Tasdiq Ahmed","orcid":"0000-0003-3297-9746","position":3,"is_corresponding":false},{"id":980762,"name":"M.D. Thouless","orcid":"0000-0002-4697-4391","position":4,"is_corresponding":false},{"id":668126,"name":"Yifan Liu","orcid":"0000-0002-3896-0002","position":5,"is_corresponding":false},{"id":282621,"name":"Shuichi Takayama","orcid":"0000-0002-4385-9080","position":6,"is_corresponding":false},{"id":282620,"name":"Ji‐Hoon Lee","orcid":"0000-0002-3542-3885","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:17:12.933204Z","pmid":"37221952","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}