{"doi":"10.1039/d3lc00745f","title":"Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells","abstract":"models to mechanistically interrogate cardiotoxicity would utilize more adult-like, mature hiPSC-derived cells in an integrated system whereby toxic drugs and protective agents can flow between hiPSC-ECs that represent systemic vasculature and hiPSC-CMs that represent heart muscle (myocardium). Such models would be useful for testing the multi-lineage cardiotoxicities of chemotherapeutic drugs such as VEGFR2/PDGFR-inhibiting tyrosine kinase inhibitors (VPTKIs). Here, we develop a multi-lineage, fully-integrated, cardiovascular organ-chip that can enhance hiPSC-EC and hiPSC-CM functional and genetic maturity, model endothelial barrier permeability, and demonstrate long-term functional stability. This microfluidic organ-chip harbors hiPSC-CMs and hiPSC-ECs on separate channels that can be subjected to active fluid flow and rhythmic biomechanical stretch. We demonstrate the utility of this cardiovascular organ-chip as a predictive platform for evaluating multi-lineage VPTKI toxicity. This study may lead to the development of new modalities for the evaluation and prevention of cancer therapy-induced cardiotoxicity.","journal":"Lab on a Chip","year":2024,"id":421773,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1051531,"name":"Amelia Jenkins","orcid":null,"position":1,"is_corresponding":false},{"id":235371,"name":"Samuel Sances","orcid":"0000-0002-9746-0681","position":2,"is_corresponding":false},{"id":1051530,"name":"Stephany Pohlman","orcid":null,"position":3,"is_corresponding":false},{"id":235372,"name":"Michael J. Workman","orcid":"0000-0003-2113-5580","position":4,"is_corresponding":false},{"id":1215293,"name":"Dylan West","orcid":null,"position":5,"is_corresponding":false},{"id":945383,"name":"Briana Ondatje","orcid":"0000-0002-1992-2625","position":6,"is_corresponding":false},{"id":1215294,"name":"Kareem El-Ghazawi","orcid":null,"position":7,"is_corresponding":false},{"id":1215295,"name":"Amanda Woodbury","orcid":null,"position":8,"is_corresponding":false},{"id":350650,"name":"Veronica J. Garcia","orcid":"0000-0002-6906-2221","position":9,"is_corresponding":false},{"id":1207818,"name":"Shachi Patel","orcid":null,"position":10,"is_corresponding":false},{"id":1051529,"name":"Madelyn Arzt","orcid":null,"position":11,"is_corresponding":false},{"id":498536,"name":"Felipe Segato Dezem","orcid":null,"position":12,"is_corresponding":false},{"id":830256,"name":"Alex Laperle","orcid":"0000-0003-1983-5844","position":13,"is_corresponding":false},{"id":696755,"name":"V. Alexandra Moser","orcid":"0000-0001-7365-0176","position":14,"is_corresponding":false},{"id":235127,"name":"Ritchie Ho","orcid":"0000-0003-1496-4436","position":15,"is_corresponding":false},{"id":830715,"name":"Nur Yucer","orcid":null,"position":16,"is_corresponding":false},{"id":232370,"name":"Jasmine Plummer","orcid":"0000-0001-7263-350X","position":17,"is_corresponding":false},{"id":696936,"name":"Robert J. Barrett","orcid":"0000-0001-5966-0706","position":18,"is_corresponding":false},{"id":232373,"name":"Clive N. Svendsen","orcid":"0000-0001-8696-3446","position":19,"is_corresponding":false},{"id":232367,"name":"Arun Sharma","orcid":"0000-0002-0607-5455","position":20,"is_corresponding":false},{"id":1051040,"name":"Maedeh Mozneb","orcid":"0000-0003-3472-3859","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T01:57:41.370244Z","pmid":"38252454","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}