{"doi":"10.1039/d3lc00648d","title":"Quantifying neutrophil extracellular trap release in a combined infection–inflammation NET-array device","abstract":"[20 nM], compared to the infection alone. We also quantified the temporal dynamics of NET release and differences in the relative areas of NETs, showing a high percentage of variable size NET release with combined PAO1 - inflammatory mediator treatment, in the device chambers. Importantly, we demonstrated reduced NET release in the confined loops of our combined infection-inflammation microsystem. Ultimately, our NET-array device stands as a valuable tool, facilitating experiments that enhance our comprehension of the spatiotemporal dynamics of NET release in response to infection within a defined microenvironment. In the future, our system can be used for high throughput and cost-effective screening of novel immunotherapies on human neutrophils in view of the importance of fine-tuning NET release in controlling pathological neutrophil-driven inflammation.","journal":"Lab on a Chip","year":2024,"id":434575,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9391,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1241368,"name":"Bhaskar Vundurthy","orcid":"0000-0002-6876-4424","position":1,"is_corresponding":false},{"id":922023,"name":"Jessica S. Hook","orcid":"0000-0001-8344-8211","position":2,"is_corresponding":false},{"id":501758,"name":"Nidhi Menon","orcid":"0000-0001-6340-684X","position":3,"is_corresponding":false},{"id":1241369,"name":"Hossein Razmi Bagtash","orcid":"0000-0002-5297-9690","position":4,"is_corresponding":false},{"id":1129626,"name":"Tarik Shihabeddin","orcid":null,"position":5,"is_corresponding":false},{"id":466922,"name":"David W. Schmidtke","orcid":"0000-0001-6404-318X","position":6,"is_corresponding":false},{"id":922024,"name":"Jessica G. Moreland","orcid":"0000-0001-8487-9494","position":7,"is_corresponding":false},{"id":271474,"name":"Marko Radic","orcid":"0000-0002-8004-282X","position":8,"is_corresponding":false},{"id":497992,"name":"Caroline N. Jones","orcid":"0000-0001-6003-9335","position":9,"is_corresponding":false},{"id":501759,"name":"Udaya Sree Datla","orcid":"0000-0001-7224-0714","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:59:58.582186Z","pmid":"38189525","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}