{"doi":"10.1039/d3fd00044c","title":"Electrochemical hydrogen isotope exchange of amines controlled by alternating current frequency","abstract":", under direct current (DC) electrolysis conditions) and pyrrolidines at 0.5 Hz. Analysis of the product distribution and D isotope incorporation at different frequencies reveals that the HIE of tetrahydroisoquinolines is limited by its slow HAT, whereas the HIE of pyrrolidines is limited by the overoxidation of its α-amino radical intermediates. The AC-frequency-dependent HIE of amines can be potentially used to achieve selective labeling of α-amine sites in one drug molecule, which will significantly impact the pharmaceutical industry.","journal":"Faraday Discussions","year":2023,"id":334407,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":853075,"name":"Disni Gunasekera","orcid":"0000-0002-6964-8337","position":1,"is_corresponding":false},{"id":853076,"name":"Jyoti P. Mahajan","orcid":"0000-0002-6071-6348","position":2,"is_corresponding":false},{"id":1062813,"name":"Joseph Frimpong","orcid":"0000-0002-1400-4876","position":3,"is_corresponding":false},{"id":995439,"name":"Zhen–Fei Liu","orcid":"0000-0002-2423-8430","position":4,"is_corresponding":false},{"id":853079,"name":"Long Luo","orcid":"0000-0001-5771-6892","position":5,"is_corresponding":false},{"id":1056365,"name":"Nibedita Behera","orcid":"0000-0002-4278-0135","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:09:48.843291Z","pmid":"37466111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}