{"doi":"10.1039/d3cc05281h","title":"Visualizing molecular deformation in fibrin networks under tensile loading <i>via</i> FLIM–FRET","abstract":"during mechanical loading. The FRET approach offers increased spatial resolution compared to our previous vibrational imaging. By using fluorescence lifetime microscopy (FLIM), we demonstrate that the combination of FRET and FLIM can probe the molecular changes in fibrin with high spatial (nanometer) and temporal (nanosecond) resolution. Our results map changes in fibrin monomer deformation during the macroscopic loading of the fibrin network, paving the way to directly visualizing the biomaterial mechanics and structure in cell-ECM scaffolds for the first time.","journal":"Chemical Communications","year":2023,"id":355307,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":565828,"name":"Yuan‐I Chen","orcid":"0000-0002-9559-2779","position":1,"is_corresponding":false},{"id":700182,"name":"Justin R. Houser","orcid":null,"position":2,"is_corresponding":false},{"id":1103277,"name":"Yujen Wang","orcid":"0000-0001-9035-9049","position":3,"is_corresponding":false},{"id":1103714,"name":"Sajjad Norouzi","orcid":null,"position":4,"is_corresponding":false},{"id":565829,"name":"Hsin‐Chih Yeh","orcid":"0000-0001-6654-5626","position":5,"is_corresponding":false},{"id":140050,"name":"Sapun H. Parekh","orcid":"0000-0001-8522-1854","position":6,"is_corresponding":false},{"id":858864,"name":"Mohammadhasan Hedayati","orcid":"0000-0001-9494-7091","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:13:16.394812Z","pmid":"37988171","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}