{"doi":"10.1039/d2tb02355e","title":"A co-formulated vaccine of irradiated cancer cells and cowpea mosaic virus improves ovarian cancer rejection","abstract":"mixtures of PEGylated CPMV and ICCs, where PEGylation of CPMV prevents ICC interactions. Flow cytometry and confocal imaging provided insights into the composition of the vaccines and their efficacy was tested using a mouse model of disseminated ovarian cancer. 67% of the mice receiving the co-formulated CPMV-ICCs survived the initial tumor challenge, and 60% of the surviving mice rejected tumors in a re-challenge experiment. In stark contrast, simple mixtures of the ICCs and (PEGylated) CPMV adjuvants were ineffective. Overall, this study highlights the importance of the co-delivery of cancer antigens and adjuvants in ovarian cancer vaccine development.","journal":"Journal of Materials Chemistry B","year":2023,"id":359104,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109240,"name":"Oscar A. Ortega‐Rivera","orcid":"0000-0002-0773-0677","position":1,"is_corresponding":false},{"id":109237,"name":"Young Hun Chung","orcid":"0000-0002-6578-8076","position":2,"is_corresponding":false},{"id":1109061,"name":"Andrea Simms","orcid":"0000-0002-3104-0588","position":3,"is_corresponding":false},{"id":109245,"name":"Nicole F. Steinmetz","orcid":"0000-0002-0130-0481","position":4,"is_corresponding":false},{"id":578459,"name":"Zhongchao Zhao","orcid":"0000-0002-3736-6677","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"36861401","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}