{"doi":"10.1039/d2sc06893a","title":"Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis","abstract":"assays revealed high diastereoselectivity, as well as a substrate tolerance by the terminal adenylation domain of the non-ribosomal peptide synthetase (NRPS) SulM toward the majority of synthetic analogs. Chemical complementation of this mutant yielded a fluorinated, bioactive monobactam through fermentation as confirmed by a combination of spectrometric data and microbiological assays. This study demonstrates site-specific functionalization of a clinically important natural product and sets in place a platform for further strain improvements and engineered NRPS-biosynthesis of non-native congeners.","journal":"Chemical Science","year":2023,"id":349254,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":927044,"name":"Lukas Kahlert","orcid":"0000-0002-7549-8603","position":1,"is_corresponding":false},{"id":915451,"name":"Rongfeng Li","orcid":"0000-0001-8879-3241","position":2,"is_corresponding":false},{"id":955295,"name":"Trevor A. Zandi","orcid":"0000-0001-7297-2667","position":3,"is_corresponding":false},{"id":1092425,"name":"Jerry Z. Yang","orcid":"0000-0002-9734-1148","position":4,"is_corresponding":false},{"id":374335,"name":"Craig A. Townsend","orcid":"0000-0003-2795-7585","position":5,"is_corresponding":false},{"id":915310,"name":"Michael S. Lichstrahl","orcid":"0000-0003-1298-4695","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:12:14.919810Z","pmid":"37035696","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}