{"doi":"10.1039/d2sc05729h","title":"Ligand engineering of Au <sub>44</sub> nanoclusters for NIR-II luminescent and photoacoustic imaging-guided cancer photothermal therapy","abstract":"NCs in the second near-infrared window (NIR-II, 1000-1700 nm) with aromatic photoacoustic (PA)/photothermal molecules through click chemistry. This design bypasses the incompatibility dilemma between photoluminescence (PL) attributes and PA/photothermal properties because the rigidity of the PA/photothermal molecules can lead to aggregation-induced emission (AIE) of the Au(i)-ligand shell of the Au NCs by constraining their nonradiative relaxation. Benefiting from strong NIR-II PL with emissions at 1080 and 1240 nm, high photothermal conversion efficiency (65.12%), low cytotoxicity, appropriate renal clearance, and enhanced permeability and retention (EPR) effect, the as-designed Au NC-based theranostic probe achieves ultradeep NIR-II PL/PA imaging-guided cancer photothermal therapy (PTT). Remarkably, 16 days after photothermal treatment guided by NIR-II PL/PA imaging, mice were all healed without tumor recurrence, while the average life span of the mice in the control groups was only 17-21 days. This study is interesting because it provides a paradigm for designing a metal NC-based theranostics probe, and it may add fundamentally and methodologically to noninvasive imaging-guided disease therapy.","journal":"Chemical Science","year":2023,"id":318373,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1026184,"name":"Xueluer Mu","orcid":null,"position":1,"is_corresponding":false},{"id":1026185,"name":"Xinxin Pan","orcid":null,"position":2,"is_corresponding":false},{"id":1025562,"name":"Ying Tang","orcid":"0000-0001-8915-3510","position":3,"is_corresponding":false},{"id":1025563,"name":"Qiaofeng Yao","orcid":"0000-0002-5129-9343","position":4,"is_corresponding":false},{"id":1025564,"name":"Yaru Wang","orcid":"0000-0003-1715-5159","position":5,"is_corresponding":false},{"id":1025565,"name":"Fuyi Jiang","orcid":"0000-0002-6557-3630","position":6,"is_corresponding":false},{"id":1025566,"name":"Fanglin Du","orcid":"0000-0002-8377-6837","position":7,"is_corresponding":false},{"id":1025567,"name":"Jianping Xie","orcid":"0000-0002-3254-5799","position":8,"is_corresponding":false},{"id":1025568,"name":"Xianfeng Zhou","orcid":"0000-0002-1408-3180","position":9,"is_corresponding":false},{"id":1025569,"name":"Xun Yuan","orcid":"0000-0002-6539-3242","position":10,"is_corresponding":false},{"id":1025561,"name":"Yang Ge","orcid":"0000-0002-3737-3279","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"37123188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}