{"doi":"10.1039/d2sc04707a","title":"The anti-breast cancer stem cell properties of gold( <scp>i</scp> )-non-steroidal anti-inflammatory drug complexes","abstract":"The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1-8 are reported. The most effective gold(i)-NSAID complex 1, containing indomethacin, exhibits greater potency for breast CSCs than bulk breast cancer cells (up to 80-fold). Furthermore, 1 reduces mammosphere viability to a better extent than a panel of clinically used breast cancer drugs and salinomycin, an established anti-breast CSC agent. Mechanistic studies suggest 1-induced breast CSC death results from breast CSC entry, cytoplasm localisation, an increase in intracellular reactive oxygen species levels, cyclooxygenase-2 downregulation and inhibition, and apoptosis. Remarkably, 1 also significantly inhibits tumour growth in a murine metastatic triple-negative breast cancer model. To the best of our knowledge, 1 is the first gold complex of any geometry or oxidation state to demonstrate anti-breast CSC properties.","journal":"Chemical Science","year":2022,"id":243476,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9619,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":874331,"name":"Chibuzor Olelewe","orcid":null,"position":1,"is_corresponding":false},{"id":875352,"name":"Jong Hyun Kim","orcid":"0000-0001-7599-7739","position":2,"is_corresponding":false},{"id":875829,"name":"Joshua Northcote‐Smith","orcid":null,"position":3,"is_corresponding":false},{"id":324223,"name":"R. Tyler Mertens","orcid":"0000-0001-8944-8386","position":4,"is_corresponding":false},{"id":875830,"name":"Ginevra Passeri","orcid":null,"position":5,"is_corresponding":false},{"id":875353,"name":"Kuldip Singh","orcid":"0000-0002-8052-6023","position":6,"is_corresponding":false},{"id":324225,"name":"Samuel G. Awuah","orcid":"0000-0003-4947-7283","position":7,"is_corresponding":false},{"id":875831,"name":"Kogularamanan Suntharalingam","orcid":null,"position":8,"is_corresponding":false},{"id":875351,"name":"Alice Johnson","orcid":"0000-0001-7676-2464","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T00:23:16.032700Z","pmid":"36741517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}