{"doi":"10.1039/d2ob01688e","title":"Thioether analogues of the pituitary neuropeptide oxytocin <i>via</i> thiol–ene macrocyclisation of unprotected peptides","abstract":"<jats:p>A radical mediated approach to macrocyclisation of unprotected peptides <jats:italic>via</jats:italic> Thiol-Ene Click for synthesis of disulfide analogues is reported.</jats:p>","journal":"Organic &amp; Biomolecular Chemistry","year":2022,"id":32704,"datarank":0.4885401018768001,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.15895641527636709,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.15895641527636709,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":172611,"name":"Conor Shine","orcid":"0000-0001-9618-3785","position":1,"is_corresponding":false},{"id":172612,"name":"Eoin M. Scanlan","orcid":"0000-0001-5176-2310","position":2,"is_corresponding":false},{"id":172613,"name":"Rita Petracca","orcid":null,"position":3,"is_corresponding":false},{"id":172610,"name":"Mark D. Nolan","orcid":"0000-0003-0385-5752","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36226353","pmcid":null,"openalex_id":"https://openalex.org/W4306167887","authors":[],"funders":[{"funder_name":"Science Foundation Ireland","grant_id":"12/RC/2275_P2","title":"SSPC_Phase 2"},{"funder_name":"Science Foundation Ireland","grant_id":"19/FFP/6667","title":"Accelerated Microfluidic Thiol-ene Mediated Native Chemical Ligation for Synthesis and Manufacture of Peptide and Protein Therapeutics"},{"funder_name":"Irish Research eLibrary","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":0.6063,"citation_percentile":0.6480455,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://pubs.rsc.org/en/content/articlepdf/2022/ob/d2ob01688e","host_type":"journal"},{"url":"https://pubs.rsc.org/en/content/articlepdf/2022/ob/d2ob01688e","host_type":"HYBRID"},{"url":"https://pubs.rsc.org/en/content/articlepdf/2022/ob/d2ob01688e","host_type":"publisher"},{"url":"http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01688E","host_type":"publisher"},{"url":"https://doi.org/10.1039/d2ob01688e","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36226353","host_type":"repository"}],"fields_of_study":["Chemical Synthesis and Analysis","Click Chemistry and Applications","Photochromic and Fluorescence Chemistry","Medicine","Chemistry","01 natural sciences","0104 chemical sciences","Sulfhydryl Compounds","Sulfides","Oxytocin","Click Chemistry","Neuropeptides","Disulfides"],"mesh_terms":["Disulfides","Neuropeptides","Oxytocin","Sulfhydryl Compounds","Sulfides","Click Chemistry"],"keywords":["Thioether","Chemistry","Disulfide bond","Thiol","Oxytocin","Neuropeptide","Combinatorial chemistry","Peptide","Click chemistry","Stereochemistry","Organic chemistry","Biochemistry","Internal medicine","Neuropeptides","Sulfhydryl Compounds","Disulfides","Sulfides"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T14:12:40.654135Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}