{"doi":"10.1039/d2an00224h","title":"Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry","abstract":"number determined by the varied lipid structure. It was also disclosed that LcGg4 and its epimers GalNAc-LcGg4 and GlcNAc-LcGg4, which are different only in the C4-configuration of their non-reducing end sugar residues, gave the same MS/MS product ions in similar relative intensities, as well as the same LC retention time, suggesting the challenge to differentiate epimeric GSLs by LC-MS. However, ion mobility spectrometry (IMS)-MS was able to efficiently separate and distinguish these epimers. This study has demonstrated the promise of IMS-MS for isomeric GSL characterization and the IMS-MS and LC-MS/MS combination for natural GSL analysis.","journal":"The Analyst","year":2022,"id":285060,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":963245,"name":"Aneirin A. Lott","orcid":"0000-0002-0424-5836","position":1,"is_corresponding":false},{"id":736857,"name":"Fanran Huang","orcid":null,"position":2,"is_corresponding":false},{"id":407225,"name":"Rajendra Rohokale","orcid":"0000-0001-8083-0466","position":3,"is_corresponding":false},{"id":407224,"name":"Qingjiang Li","orcid":"0000-0001-5535-6993","position":4,"is_corresponding":false},{"id":896604,"name":"Hernando J. Olivos","orcid":null,"position":5,"is_corresponding":false},{"id":258510,"name":"Sixue Chen","orcid":"0000-0002-6690-7612","position":6,"is_corresponding":false},{"id":407226,"name":"Zhongwu Guo","orcid":"0000-0001-5302-6456","position":7,"is_corresponding":false},{"id":736406,"name":"Tianqi Gao","orcid":"0000-0002-0577-1352","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"35695136","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}