{"doi":"10.1039/d1nj00380a","title":"Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery","abstract":"In an effort to synthesize a library of bioactive molecules, we present an efficient synthesis of fused-thiazole derivatives of natural products and approved drugs by using an environmentally usable solvent, acetic acid, and without any external reagent. Cholestenone, ethisterone, progesterone, and nootkatone-derived epoxyketones have been utilized to synthesize 50 novel compounds. The plausible mechanism of the reaction has been determined by theoretical calculation using M06-2X/6-31+G(d,p). These novel molecules have been tested against cancer cell lines and pathogenic bacterial strains. Several ethisterone-based fused-thiazole compounds are found to be potent growth inhibitors of cancer cell lines at submicromolar concentrations.","journal":"New Journal of Chemistry","year":2021,"id":180110,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9443,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":728572,"name":"Mohamad Akbar Ali","orcid":"0000-0003-3813-631X","position":1,"is_corresponding":false},{"id":712116,"name":"Ibrahim S. Alkhaibari","orcid":null,"position":2,"is_corresponding":false},{"id":728573,"name":"Subrata Roy","orcid":"0000-0003-2263-8112","position":3,"is_corresponding":false},{"id":306730,"name":"Victor W. Day","orcid":null,"position":4,"is_corresponding":false},{"id":345963,"name":"Mohammad A. Alam","orcid":"0000-0003-0258-3732","position":5,"is_corresponding":false},{"id":346749,"name":"Rawan Alnufaie","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:47:53.089578Z","pmid":"33840994","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}