{"doi":"10.1039/d1lc00265a","title":"Fabrication of tunable, high-molecular-weight polymeric nanoparticles <i>via</i> ultrafast acoustofluidic micromixing","abstract":"High-molecular-weight polymeric nanoparticles are critical to increasing the loading efficacy and tuning the release profile of targeted molecules for medical diagnosis, imaging, and therapeutics. Although a number of microfluidic approaches have attained reproducible nanoparticle synthesis, it is still challenging to fabricate nanoparticles from high-molecular-weight polymers in a size and structure-controlled manner. In this work, an acoustofluidic platform is developed to synthesize size-tunable, high-molecular-weight (>45 kDa) poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) nanoparticles without polymer aggregation by exploiting the characteristics of complete and ultrafast mixing. Moreover, the acoustofluidic approach achieves two features that have not been achieved by existing microfluidic approaches: (1) multi-step (≥2) sequential nanoprecipitation in a single device, and (2) synthesis of core-shell structured PLGA-PEG/lipid nanoparticles with high molecular weights. The developed platform expands microfluidic potential in nanomaterial synthesis, where high-molecular-weight polymers, multiple reagents, or sequential nanoprecipitations are needed.","journal":"Lab on a Chip","year":2021,"id":162058,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274160,"name":"Po‐Hsun Huang","orcid":"0000-0001-9600-0141","position":1,"is_corresponding":false},{"id":276286,"name":"Heying Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":407336,"name":"Joseph Rich","orcid":"0000-0002-6249-2093","position":3,"is_corresponding":false},{"id":235105,"name":"Hunter Bachman","orcid":"0000-0002-2356-5392","position":4,"is_corresponding":false},{"id":276285,"name":"Jennifer Ye","orcid":null,"position":5,"is_corresponding":false},{"id":650118,"name":"Wenfen Zhang","orcid":"0000-0003-3248-7477","position":6,"is_corresponding":false},{"id":274158,"name":"Chuyi Chen","orcid":"0000-0001-5733-4261","position":7,"is_corresponding":false},{"id":274159,"name":"Zhemiao Xie","orcid":"0000-0002-1672-3479","position":8,"is_corresponding":false},{"id":266321,"name":"Zhenhua Tian","orcid":"0000-0002-1903-5604","position":9,"is_corresponding":false},{"id":457295,"name":"Putong Kang","orcid":"0000-0002-1762-1239","position":10,"is_corresponding":false},{"id":307730,"name":"Hai Fu","orcid":"0000-0002-6322-3186","position":11,"is_corresponding":false},{"id":235107,"name":"Tony Jun Huang","orcid":"0000-0003-1205-3313","position":12,"is_corresponding":false},{"id":274156,"name":"Shuaiguo Zhao","orcid":"0000-0002-0139-8466","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T23:45:00.600065Z","pmid":"33978043","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}