{"doi":"10.1039/d1lc00259g","title":"Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets","abstract":"mediating tension transmission and platelet adhesion under low flow rates has been obtained, and the process of platelet clustering at post-stenotic regions has been demonstrated. We found that flowing shear force can postpone the integrin-mediated tension transmission and platelet adhesion. We further evaluated the effect of Y-27632, a ROCK inhibitor that has been proven to reduce integrin-mediated platelet adhesion, at a series of concentrations and demonstrated that microfluidic chips with integrin tension sensors are sensitive to the concentration-dependent effects of Y-27632. Given their low cost and scalable throughput, these chips are ideal technical platforms for biological studies of platelets at flowing status and for platelet inhibitor or potential antiplatelet drug screening.","journal":"Lab on a Chip","year":2021,"id":178528,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484396,"name":"Anwesha Sarkar","orcid":"0000-0002-4267-7242","position":1,"is_corresponding":false},{"id":724322,"name":"Yongliang Wang","orcid":"0000-0002-5480-9927","position":2,"is_corresponding":false},{"id":724323,"name":"Chao Song","orcid":"0000-0001-9940-9786","position":3,"is_corresponding":false},{"id":484397,"name":"Dana N. LeVine","orcid":"0000-0002-1089-5640","position":4,"is_corresponding":false},{"id":484400,"name":"Xuefeng Wang","orcid":"0000-0002-3301-3196","position":5,"is_corresponding":false},{"id":724324,"name":"Long Que","orcid":"0000-0002-1603-4219","position":6,"is_corresponding":false},{"id":724321,"name":"Subin Mao","orcid":"0000-0001-8841-0909","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:47:40.592580Z","pmid":"34180491","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}