{"doi":"10.1039/d1cs00269d","title":"Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic design","abstract":"Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. 'Active' nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy.","journal":"Chemical Society Reviews","year":2023,"id":325236,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488453,"name":"Aarohi Gupta","orcid":"0000-0003-1303-1159","position":1,"is_corresponding":false},{"id":1042757,"name":"Olga Bednova","orcid":"0000-0002-6737-1784","position":2,"is_corresponding":false},{"id":1043411,"name":"Gaël Coulombe","orcid":null,"position":3,"is_corresponding":false},{"id":1042758,"name":"Dipika V. Patel","orcid":"0000-0001-9994-4631","position":4,"is_corresponding":false},{"id":232161,"name":"Vincent M. Rotello","orcid":"0000-0002-5184-5439","position":5,"is_corresponding":false},{"id":1042759,"name":"Jeffrey V. Leyton","orcid":"0000-0001-6870-3819","position":6,"is_corresponding":false},{"id":304708,"name":"Ritabrita Goswami","orcid":"0000-0003-3812-6322","position":0,"is_corresponding":true}],"reference_count":160,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:08:22.919783Z","pmid":"38031452","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}