{"doi":"10.1039/d1cc06525d","title":"3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC","abstract":"In this study, we identified 3-aminophthalic acid as a new ligand of cereblon (CRBN) E3 ubiquitin ligase and developed a phthalic acid-based O'PROTAC for degradation of the ERG transcription factor. This phthalic acid-based O'PROTAC presented an efficacy in degrading ERG comparable to those displayed by pomalidomide-based ERG O'PROTACs. Moreover, phthalic acid-being more chemically stable and economical than classical immunomodulatory drugs (IMiDs)-represents, as a ligand, a new alternative for the development of PROTACs, especially O'PROTACs.","journal":"Chemical Communications","year":2022,"id":255066,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":632837,"name":"Jingwei Shao","orcid":"0009-0006-0490-3161","position":1,"is_corresponding":false},{"id":633751,"name":"Donglin Ding","orcid":null,"position":2,"is_corresponding":false},{"id":632840,"name":"Yunqian Pan","orcid":"0000-0003-0912-8978","position":3,"is_corresponding":false},{"id":793131,"name":"Phuc Tran","orcid":"0009-0007-4676-8161","position":4,"is_corresponding":false},{"id":453452,"name":"Wei Yan","orcid":"0000-0003-1535-3100","position":5,"is_corresponding":false},{"id":902750,"name":"Zhenyu Wang","orcid":"0000-0002-5114-435X","position":6,"is_corresponding":false},{"id":245897,"name":"Hongyu Li","orcid":"0000-0001-9212-2010","position":7,"is_corresponding":false},{"id":409827,"name":"Haojie Huang","orcid":"0000-0003-2751-6413","position":8,"is_corresponding":false},{"id":632838,"name":"Yuqian Yan","orcid":"0000-0002-1646-7276","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T00:25:12.987829Z","pmid":"35080528","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}