{"doi":"10.1039/d0tb01453b","title":"Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy","abstract":"Development of bioresponsive theranostic nanoparticles to enhance cancer diagnostics and control cancer metastasis is highly desirable. In this study, we developed such a bioresponsive theranostic nanoparticle for synergistic photoimmunotherapy. In particular, these nanoparticles were constructed by embedding indocyanine green (ICG) into Mn2+-doped amorphous calcium carbonate (ACC(Mn)) nanoparticles, followed by loading of the Toll-like-receptor-7 agonist imiquimod (IMQ). The IMQ@ACC(Mn)-ICG/PEG nanoparticles respond to the acidic pH of the tumor microenvironment (TME) and co-deliver ICG and IMQ into the tumor. Selective phototherapy was achieved upon activation using a near-infrared laser. In the presence of IMQ and arising from phototherapeutically treated tumor cells, tumor-associated antigens give rise to a strong antitumor immune response. Reversal of the immunosuppressive TME via H+ scavenging of the tumor through ACC nanoparticles effectively inhibits tumor metastases. Moreover, the combination of ICG and Mn2+ also serves as an advanced contrast agent for cancer multimode imaging. Overall, these bioresponsive nanoparticles provide a promising approach for cancer theranostics with promising potential for future clinical translation.","journal":"Journal of Materials Chemistry B","year":2020,"id":96022,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":272331,"name":"Benqing Zhou","orcid":"0000-0003-1131-7591","position":1,"is_corresponding":false},{"id":476634,"name":"Lu Wang","orcid":"0000-0001-8412-2985","position":2,"is_corresponding":false},{"id":268600,"name":"Feifan Zhou","orcid":"0000-0001-8213-507X","position":3,"is_corresponding":false},{"id":273256,"name":"Nataliya Smith","orcid":null,"position":4,"is_corresponding":false},{"id":273257,"name":"Debra Saunders","orcid":null,"position":5,"is_corresponding":false},{"id":272335,"name":"Rheal A. Towner","orcid":"0000-0001-7368-8983","position":6,"is_corresponding":false},{"id":272336,"name":"Jun Song","orcid":"0000-0002-2321-7064","position":7,"is_corresponding":false},{"id":150416,"name":"Junle Qu","orcid":"0000-0001-7833-4711","position":8,"is_corresponding":false},{"id":268603,"name":"Wei R. Chen","orcid":"0000-0002-7133-5794","position":9,"is_corresponding":false},{"id":268601,"name":"Meng Wang","orcid":"0000-0003-4170-0348","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32812632","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}