{"doi":"10.1039/d0sc01795g","title":"A poly-ADP-ribose polymer-based antibody-drug conjugate","abstract":") to protein residues, forming linear or branched poly-ADP-ribose (PAR) polymers. In this study, we explored a new concept of utilizing functionalized PAR polymers for targeted drug delivery. This was achieved by rapid and efficient generation of auto-PARylated PARP1 with 3'-azido ADP-riboses and subsequent conjugations of anti-human epidermal growth factor receptor 2 (HER2) antibodies and monomethyl auristatin F (MMAF) payloads. This designed PARylated PARP1-antibody-MMAF conjugate could potently kill HER2-expressing cancer cells in high specificity. This proof-of-principle work demonstrates the feasibility of production of PAR polymer-based antibody-drug conjugate and its application in targeted delivery. The PAR polymer-based conjugates may lead to new types of therapeutics with potentially improved physicochemical and pharmacological properties.","journal":"Chemical Science","year":2020,"id":102529,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":500680,"name":"Xiaonan Zhang","orcid":"0000-0002-9780-6507","position":1,"is_corresponding":false},{"id":500681,"name":"Jingwen Chen","orcid":"0000-0002-5756-3336","position":2,"is_corresponding":false},{"id":500682,"name":"Qinqin Cheng","orcid":"0000-0003-0138-1944","position":3,"is_corresponding":false},{"id":501874,"name":"Hua Pei","orcid":null,"position":4,"is_corresponding":false},{"id":500683,"name":"Stan G. Louie","orcid":"0000-0001-5941-6690","position":5,"is_corresponding":false},{"id":486449,"name":"Yong Zhang","orcid":"0000-0002-3132-8557","position":6,"is_corresponding":false},{"id":500679,"name":"Xiaojing Shi","orcid":"0000-0002-7258-0636","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T22:41:53.173268Z","pmid":"33623656","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}