{"doi":"10.1039/d0nh00077a","title":"A brain tumor-homing tetra-peptide delivers a nano-therapeutic for more effective treatment of a mouse model of glioblastoma","abstract":"Organ-specific cell-penetrating peptides (CPPs) are a class of molecules that can be highly effective at delivering therapeutic cargoes, and they are currently of great interest in cancer treatment strategies. Herein, we describe a new CPP (amino acid sequence serine-isoleucine-tyrosine-valine, or SIWV) that homes to glioblastoma multiforme (GBM) brain tumor tissues with remarkable specificity in vitro and in vivo. The SIWV sequence was identified from an isoform of annexin-A3 (AA3H), a membrane-interacting human protein. The mechanism of intracellular permeation is proposed to follow a caveolin-mediated endocytotic pathway, based on in vitro and in vivo receptor inhibition and genetic knockdown studies. Feasibility as a targeting agent for therapeutics is demonstrated in a GBM xenograft mouse model, where porous silicon nanoparticles (pSiNPs) containing the clinically relevant anticancer drug SN-38 are grafted with SIWV via a poly-(ethylene glycol) (PEG) linker. The formulation shows enhanced in vivo targeting ability relative to a formulation employing a scrambled control peptide, and significant (P < 0.05) therapeutic efficacy relative to free SN-38 in the GBM xenograft animal model.","journal":"Nanoscale Horizons","year":2020,"id":65781,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348267,"name":"Jeong-Eun Jang","orcid":"0000-0002-4053-7430","position":1,"is_corresponding":false},{"id":304760,"name":"Eugene Huh","orcid":"0009-0001-1090-1705","position":2,"is_corresponding":false},{"id":348268,"name":"Seong Jae Kang","orcid":"0000-0003-0982-3604","position":3,"is_corresponding":false},{"id":348269,"name":"Dae‐Ro Ahn","orcid":"0000-0001-7108-5855","position":4,"is_corresponding":false},{"id":348270,"name":"Jae Seung Kang","orcid":"0000-0001-6587-9579","position":5,"is_corresponding":false},{"id":342573,"name":"Michael J. Sailor","orcid":"0000-0002-4809-9826","position":6,"is_corresponding":false},{"id":348271,"name":"Seung Geun Yeo","orcid":"0000-0001-8021-1024","position":7,"is_corresponding":false},{"id":304766,"name":"Myung Sook Oh","orcid":"0000-0001-8189-4066","position":8,"is_corresponding":false},{"id":304767,"name":"Dokyoung Kim","orcid":"0000-0002-7756-3560","position":9,"is_corresponding":false},{"id":348272,"name":"Hyo Young Kim","orcid":"0000-0002-1834-5766","position":10,"is_corresponding":false},{"id":348266,"name":"Rae Hyung Kang","orcid":"0000-0001-9380-6553","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:13:43.728351Z","pmid":"32510090","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}