{"doi":"10.1039/d0na01007c","title":"The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles","abstract":"light-matter interactions. Finite-difference time-domain (FDTD) simulation data indicate a 4-orders-of-magnitude Raman enhancement in \"hot spot\" positions when gold nanoparticles form aggregates. Using a portable Raman analyzer, our reported data demonstrate that our antibody and 4-aminothiophenol attached gold nanoparticle-based SERS probe has the capability to detect COVID-19 antigen even at a concentration of 4 picograms (pg) per mL and virus at a concentration of 18 virus particles per mL within a 5 minute time period. Using HEK293T cells, which express angiotensin-converting enzyme 2 (ACE2), by which SARS-CoV-2 enters human cells, we show that anti-spike antibody attached gold nanoparticles have the capability to inhibit infection by the virus. Our reported data show that antibody attached gold nanoparticles bind to SARS-CoV-2 spike protein, thereby inhibiting the virus from binding to cell receptors, which stops virus infection and spread. It also has the capability to destroy the lipid membrane of the virus.","journal":"Nanoscale Advances","year":2021,"id":148280,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":130,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":630787,"name":"Ye Gao","orcid":"0000-0002-0943-2358","position":1,"is_corresponding":false},{"id":630788,"name":"Shamily Patibandla","orcid":"0000-0002-0497-5046","position":2,"is_corresponding":false},{"id":300826,"name":"Dipanwita Mitra","orcid":"0000-0002-4413-0195","position":3,"is_corresponding":false},{"id":300827,"name":"Martin G. McCandless","orcid":"0000-0002-9068-8683","position":4,"is_corresponding":false},{"id":631591,"name":"Lauren A. Fassero","orcid":null,"position":5,"is_corresponding":false},{"id":631592,"name":"Kalein Gates","orcid":null,"position":6,"is_corresponding":false},{"id":300829,"name":"Ritesh Tandon","orcid":"0000-0001-8996-8840","position":7,"is_corresponding":false},{"id":617931,"name":"Paresh Chandra Ray","orcid":"0000-0001-5398-9930","position":8,"is_corresponding":false},{"id":630786,"name":"Avijit Pramanik","orcid":"0000-0002-4623-2099","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:42:41.063423Z","pmid":"34381960","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}