{"doi":"10.1039/d0lc01216e","title":"An <i>in vitro</i> vascularized micro-tumor model of human colorectal cancer recapitulates <i>in vivo</i> responses to standard-of-care therapy","abstract":"Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline highlights the need for improved, physiologically-relevant in vitro models that can better serve as reliable drug-screening and disease modeling tools. The vascularized micro-tumor (VMT) is a novel three-dimensional model system (tumor-on-a-chip) that recapitulates the complex human tumor microenvironment, including perfused vasculature, within a transparent microfluidic device, allowing real-time study of drug responses and tumor-stromal interactions. Here we have validated this microphysiological system (MPS) platform for the study of colorectal cancer (CRC), the second leading cause of cancer-related deaths, by showing that gene expression, tumor heterogeneity, and treatment responses in the VMT more closely model CRC tumor clinicopathology than current standard drug screening modalities, including 2-dimensional monolayer culture and 3-dimensional spheroids.","journal":"Lab on a Chip","year":2021,"id":148447,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9345,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":631885,"name":"Silva Movsesyan","orcid":"0000-0002-3167-3430","position":1,"is_corresponding":false},{"id":239855,"name":"Quy Nguyen","orcid":"0000-0002-7016-1155","position":2,"is_corresponding":false},{"id":633302,"name":"Giselle Burton-Sojo","orcid":null,"position":3,"is_corresponding":false},{"id":633303,"name":"Ani Tankazyan","orcid":null,"position":4,"is_corresponding":false},{"id":297945,"name":"Jie Wu","orcid":"0000-0003-2759-5879","position":5,"is_corresponding":false},{"id":532683,"name":"Tuyen Hoang","orcid":null,"position":6,"is_corresponding":false},{"id":631886,"name":"Zhao Da","orcid":"0000-0002-8292-5036","position":7,"is_corresponding":false},{"id":242832,"name":"Shuxiong Wang","orcid":"0000-0002-1021-9853","position":8,"is_corresponding":false},{"id":283471,"name":"Michaela M.S. Hatch","orcid":null,"position":9,"is_corresponding":false},{"id":633304,"name":"Elizabeth Celaya","orcid":null,"position":10,"is_corresponding":false},{"id":633305,"name":"Samantha Gomez","orcid":null,"position":11,"is_corresponding":false},{"id":554355,"name":"George Chen","orcid":"0000-0002-1342-0835","position":12,"is_corresponding":false},{"id":570772,"name":"Ryan T. Davis","orcid":"0000-0003-0036-4085","position":13,"is_corresponding":false},{"id":631887,"name":"Kevin Nee","orcid":"0000-0002-9892-0598","position":14,"is_corresponding":false},{"id":344670,"name":"Nicholas Pervolarakis","orcid":"0000-0001-6210-4022","position":15,"is_corresponding":false},{"id":570774,"name":"Devon A. Lawson","orcid":"0000-0003-1692-0517","position":16,"is_corresponding":false},{"id":239858,"name":"Kai Kessenbrock","orcid":"0000-0003-0410-6104","position":17,"is_corresponding":false},{"id":579257,"name":"Abraham P. Lee","orcid":"0000-0001-8378-6616","position":18,"is_corresponding":false},{"id":251027,"name":"John Lowengrub","orcid":"0000-0003-1759-0900","position":19,"is_corresponding":false},{"id":347751,"name":"Marian L. Waterman","orcid":"0000-0003-4823-4968","position":20,"is_corresponding":false},{"id":281522,"name":"Christopher C.W. Hughes","orcid":"0000-0002-3223-830X","position":21,"is_corresponding":false},{"id":631884,"name":"Stephanie J. Hachey","orcid":"0000-0002-0314-3459","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:42:46.224799Z","pmid":"33605955","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}