{"doi":"10.1039/d0cc05165a","title":"A pH-sensitive eosin-block copolymer delivers proteins intracellularly","abstract":"There is great interest in developing strategies to deliver proteins into the cytoplasm of cells. We report here a PEG-poly-eosin block copolymer (PEG-pEosin) that can encapsulate proteins and release them in active form under mildly acidic conditions. A PEG-pEosin formulation composed of Cre and the endosomolytic protein LLO efficiently performed gene editing in cells and in the brains of mice after an intracranial injection.","journal":"Chemical Communications","year":2020,"id":114140,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":492016,"name":"Hesong Han","orcid":"0000-0001-5545-5238","position":1,"is_corresponding":false},{"id":537535,"name":"Jan Tůma","orcid":"0000-0002-7197-8482","position":2,"is_corresponding":false},{"id":320284,"name":"Joachim Justad Røise","orcid":"0000-0002-1794-7570","position":3,"is_corresponding":false},{"id":500740,"name":"I-Che Li","orcid":"0000-0002-5819-8094","position":4,"is_corresponding":false},{"id":320283,"name":"Jie Li","orcid":"0000-0003-0189-2787","position":5,"is_corresponding":false},{"id":537536,"name":"Hye Young Lee","orcid":"0000-0002-3150-6886","position":6,"is_corresponding":false},{"id":235839,"name":"Niren Murthy","orcid":"0000-0002-7815-7337","position":7,"is_corresponding":false},{"id":537534,"name":"Sören Reinhard","orcid":"0000-0003-1348-5919","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-18T23:13:29.674622Z","pmid":"33111731","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}