{"doi":"10.1039/d0cc04873a","title":"Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the <i>Staphylococcus aureus</i> receptor histidine kinase, AgrC","abstract":"We combined mRNA display technology with lipid-nanodisc based selections and identified high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase AgrC as potent inhibitors of Staphylococcus aureus quorum sensing-modulated virulence. Our study highlights the potential of this integrated approach for identifying functional modulators of integral membrane proteins.","journal":"Chemical Communications","year":2020,"id":101684,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497506,"name":"Mareike M. Wiedmann","orcid":"0000-0002-4728-7155","position":1,"is_corresponding":false},{"id":497507,"name":"Aishan Zhao","orcid":"0000-0002-9010-7981","position":2,"is_corresponding":false},{"id":498430,"name":"Ivelisse Rodriguez Pagan","orcid":null,"position":3,"is_corresponding":false},{"id":497508,"name":"Richard P. Novick","orcid":"0000-0003-4418-7893","position":4,"is_corresponding":false},{"id":426660,"name":"Hiroaki Suga","orcid":"0000-0002-5298-9186","position":5,"is_corresponding":false},{"id":298832,"name":"Tom W. Muir","orcid":"0000-0001-9635-0344","position":6,"is_corresponding":false},{"id":497505,"name":"Qian Xie","orcid":"0000-0003-1984-5073","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-18T22:40:22.678835Z","pmid":"32820778","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}