{"doi":"10.1039/c9sc04336e","title":"Target identification among known drugs by deep learning from heterogeneous networks","abstract":"= 0.43 μM) of human retinoic-acid-receptor-related orphan receptor-gamma t (ROR-γt). Furthermore, by specifically targeting ROR-γt, topotecan reveals a potential therapeutic effect in a mouse model of multiple sclerosis. In summary, deepDTnet offers a powerful network-based deep learning methodology for target identification to accelerate drug repurposing and minimize the translational gap in drug development.","journal":"Chemical Science","year":2020,"id":48721,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":354,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231860,"name":"Siyi Zhu","orcid":"0000-0003-2552-2203","position":1,"is_corresponding":false},{"id":231861,"name":"Weiqiang Lü","orcid":"0000-0003-1349-6597","position":2,"is_corresponding":false},{"id":231862,"name":"Zehui Liu","orcid":"0000-0002-8026-449X","position":3,"is_corresponding":false},{"id":231863,"name":"Jin Huang","orcid":"0000-0002-0698-1693","position":4,"is_corresponding":false},{"id":105381,"name":"Yadi Zhou","orcid":"0000-0002-6049-0545","position":5,"is_corresponding":false},{"id":231864,"name":"Jiansong Fang","orcid":"0000-0002-6998-5384","position":6,"is_corresponding":false},{"id":105384,"name":"Yin Huang","orcid":"0000-0001-9678-2630","position":7,"is_corresponding":false},{"id":231865,"name":"Huimin Guo","orcid":"0009-0007-0490-2289","position":8,"is_corresponding":false},{"id":12406,"name":"Lang Li","orcid":"0000-0002-0746-1809","position":9,"is_corresponding":false},{"id":231866,"name":"Bruce D. Trapp","orcid":"0000-0001-6682-3737","position":10,"is_corresponding":false},{"id":70301,"name":"Ruth Nussinov","orcid":"0000-0002-8115-6415","position":11,"is_corresponding":false},{"id":228051,"name":"Charis Eng","orcid":"0000-0002-3693-5145","position":12,"is_corresponding":false},{"id":87927,"name":"Joseph Loscalzo","orcid":"0000-0002-1153-8047","position":13,"is_corresponding":false},{"id":69831,"name":"Feixiong Cheng","orcid":"0000-0002-1736-2847","position":14,"is_corresponding":false},{"id":231859,"name":"Xiangxiang Zeng","orcid":"0000-0003-1081-7658","position":0,"is_corresponding":true}],"reference_count":125,"raw_metadata":null,"created_at":"2026-07-18T20:35:18.908826Z","pmid":"34123272","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}