{"doi":"10.1039/c9cc09891g","title":"Engineering bromodomains with a photoactive amino acid by engaging ‘Privileged’ tRNA synthetases","abstract":"Site-specific placement of unnatural amino acids, particularly those responsive to light, offers an elegant approach to control protein function and capture their fleeting 'interactome'. Herein, we have resurrected 4-(trifluoromethyldiazirinyl)-phenylalanine, an underutilized photo-crosslinker, by introducing several key features including easy synthetic access, site-specific incorporation by 'privileged' synthetases and superior crosslinking efficiency, to develop photo-crosslinkable bromodomains suitable for 'interactome' profiling.","journal":"Chemical Communications","year":2020,"id":83326,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428749,"name":"Babu Sudhamalla","orcid":"0000-0002-6610-1424","position":1,"is_corresponding":false},{"id":428750,"name":"Philip Z. Mannes","orcid":"0000-0003-3080-8863","position":2,"is_corresponding":false},{"id":429540,"name":"Sushma Sappa","orcid":null,"position":3,"is_corresponding":false},{"id":428751,"name":"Sam Kavoosi","orcid":"0000-0003-2618-5528","position":4,"is_corresponding":false},{"id":428752,"name":"Debasis Dey","orcid":"0000-0002-3612-860X","position":5,"is_corresponding":false},{"id":428753,"name":"Sinan Wang","orcid":"0000-0002-2888-2557","position":6,"is_corresponding":false},{"id":428754,"name":"Kabirul Islam","orcid":"0000-0002-8680-6130","position":7,"is_corresponding":false},{"id":429539,"name":"Shana Wagner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T21:54:09.383533Z","pmid":"32107512","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}