{"doi":"10.1039/c9cc09849f","title":"Synthesis and characterization of high affinity fluorogenic α-synuclein probes","abstract":"Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small molecule binding sites.","journal":"Chemical Communications","year":2020,"id":94643,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323326,"name":"John J. Ferrie","orcid":"0000-0001-7934-7266","position":1,"is_corresponding":false},{"id":323328,"name":"Bieneke Janssen","orcid":"0000-0001-9573-8558","position":2,"is_corresponding":false},{"id":323331,"name":"Chia‐Ju Hsieh","orcid":"0000-0002-2833-7727","position":3,"is_corresponding":false},{"id":323334,"name":"Thomas J. A. Graham","orcid":"0000-0002-3733-4106","position":4,"is_corresponding":false},{"id":472335,"name":"Kui-ying Xu","orcid":null,"position":5,"is_corresponding":false},{"id":471384,"name":"Conor M. Haney","orcid":"0000-0001-7557-0399","position":6,"is_corresponding":false},{"id":27604,"name":"Virginia M.‐Y. Lee","orcid":"0000-0003-3536-6902","position":7,"is_corresponding":false},{"id":27606,"name":"John Q. Trojanowski","orcid":"0000-0002-9239-8794","position":8,"is_corresponding":false},{"id":239973,"name":"E. James Petersson","orcid":"0000-0003-3854-9210","position":9,"is_corresponding":false},{"id":323335,"name":"Robert H. Mach","orcid":"0000-0002-7645-2869","position":10,"is_corresponding":false},{"id":323327,"name":"Zsofia Lengyel‐Zhand","orcid":"0000-0001-8447-8631","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T22:33:00.770265Z","pmid":"32104795","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}