{"doi":"10.1039/c9cc09170j","title":"Substrate interaction inhibits γ-secretase production of amyloid-β peptides","abstract":"Combining NMR, mass spectrometry, AlphaLISA and cell assays, we discovered a compound C1 that binds C-terminal juxtamembrane lysines at the transmembrane domain of the amyloid precursor protein (APPTM) and inhibits γ-secretase production of amyloid-β with μM IC50. Our work suggests that targeting APPTM is a novel and viable strategy in AD drug discovery.","journal":"Chemical Communications","year":2020,"id":114677,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":539193,"name":"Yuanyuan Xiao","orcid":"0000-0003-0216-938X","position":1,"is_corresponding":false},{"id":255563,"name":"Xinyue Liu","orcid":"0000-0002-0934-4155","position":2,"is_corresponding":false},{"id":539194,"name":"Soohyun Kim","orcid":"0000-0003-0628-3737","position":3,"is_corresponding":false},{"id":233987,"name":"Xianzhong Wu","orcid":null,"position":4,"is_corresponding":false},{"id":230254,"name":"Marilia Barros","orcid":"0000-0002-4628-3048","position":5,"is_corresponding":false},{"id":539195,"name":"Ran Zhuang","orcid":"0000-0002-3614-0422","position":6,"is_corresponding":false},{"id":117238,"name":"Xuben Hou","orcid":"0000-0002-8346-9001","position":7,"is_corresponding":false},{"id":255564,"name":"Yingkai Zhang","orcid":"0000-0002-4984-3354","position":8,"is_corresponding":false},{"id":276811,"name":"Nikolaos K. Robakis","orcid":null,"position":9,"is_corresponding":false},{"id":233994,"name":"Yue‐Ming Li","orcid":null,"position":10,"is_corresponding":false},{"id":36130,"name":"Jonathan S. Dordick","orcid":"0000-0001-7802-3702","position":11,"is_corresponding":false},{"id":291767,"name":"Iban Ubarretxena‐Belandia","orcid":"0000-0003-4082-4349","position":12,"is_corresponding":false},{"id":255565,"name":"Chunyu Wang","orcid":"0000-0001-5165-7959","position":13,"is_corresponding":false},{"id":255562,"name":"Jing Zhao","orcid":"0000-0002-7031-3024","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:13:33.226937Z","pmid":"32016207","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}