{"doi":"10.1039/c8sc05771k","title":"A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation","abstract":"<p>This study demonstrates the modulation of amyloid aggregation of two human proteins, amyloid-beta and amylin, by a cationic polymer (PMAQA).</p>","journal":"Chemical Science","year":2019,"id":648245,"datarank":1.7383753428688027,"base_score":4.204692619390966,"endowment":4.204692619390966,"self_citation_contribution":0.6307038929086449,"citation_network_contribution":1.1076714499601579,"self_endowment_contribution":0.6307038929086449,"citer_contribution":1.1076714499601579,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":43,"citers_with_citation_signal":41,"citers_with_endowment":41,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1689231,"name":"Takuya Genjo","orcid":null,"position":1,"is_corresponding":false},{"id":575136,"name":"Takahiro W. Nakayama","orcid":null,"position":2,"is_corresponding":false},{"id":357275,"name":"Andrea K. Stoddard","orcid":null,"position":3,"is_corresponding":false},{"id":774127,"name":"Toshio Ando","orcid":"0000-0001-8819-154X","position":4,"is_corresponding":false},{"id":1689233,"name":"Kazuma Yasuhara","orcid":null,"position":5,"is_corresponding":false},{"id":63441,"name":"Carol A. Fierke","orcid":"0000-0002-1481-0579","position":6,"is_corresponding":false},{"id":256242,"name":"Ayyalusamy Ramamoorthy","orcid":"0000-0003-1964-1900","position":7,"is_corresponding":false},{"id":308759,"name":"Bikash R. Sahoo","orcid":"0000-0002-3683-1178","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation","abstract":"<p>This study demonstrates the modulation of amyloid aggregation of two human proteins, amyloid-beta and amylin, by a cationic polymer (PMAQA).</p>","is_dataset_classified":null,"base_score":4.204692619390966,"endowment":4.204692619390966,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31015938","pmcid":"PMC6457205","openalex_id":"https://openalex.org/W2888441838","authors":[],"funders":[{"funder_name":"National Institute on Aging","grant_id":"AG048934","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM040602","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG048934","title":null},{"funder_name":"Osaka University","grant_id":"","title":null}],"total_grants":4,"fwci":5.5323,"citation_percentile":0.9679751,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":17},{"year":2021,"count":14},{"year":2022,"count":10},{"year":2023,"count":7},{"year":2024,"count":7},{"year":2025,"count":5}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc05771k","host_type":"journal"},{"url":"https://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc05771k","host_type":"publisher"},{"url":"http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC05771K","host_type":"publisher"},{"url":"https://doi.org/10.1039/c8sc05771k","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31015938","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6457205","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6457205","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6457205?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Alzheimer's disease research and treatments","Computational Drug Discovery Methods","Cholinesterase and Neurodegenerative Diseases"],"mesh_terms":[],"keywords":["Amylin","Cationic polymerization","Copolymer","Agonist","Fibrillation","Amyloid (mycology)","Antagonist","Chemistry","Polymer chemistry","Polymer","Internal medicine","Medicine","Endocrinology","Biochemistry","Receptor","Diabetes mellitus","Organic chemistry","Atrial fibrillation","Inorganic chemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:24:16.943350Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}