{"doi":"10.1039/c1nr10311c","title":"Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls","abstract":null,"journal":"Nanoscale","year":2011,"id":606557,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1557190,"name":"Sergey A. Dergunov","orcid":null,"position":1,"is_corresponding":false},{"id":537977,"name":"Yi Zhang","orcid":"0000-0003-1780-0963","position":2,"is_corresponding":false},{"id":1299612,"name":"Xi Li","orcid":"0009-0008-4480-8251","position":3,"is_corresponding":false},{"id":440406,"name":"Qingxin Mu","orcid":"0000-0003-4952-6591","position":4,"is_corresponding":false},{"id":656728,"name":"Qiu Zhang","orcid":"0000-0002-0829-7756","position":5,"is_corresponding":false},{"id":1241495,"name":"Guibin Jiang","orcid":"0000-0002-6335-3917","position":6,"is_corresponding":false},{"id":1557191,"name":"Eugene Pinkhassik","orcid":null,"position":7,"is_corresponding":false},{"id":1102150,"name":"Bing Yan","orcid":"0000-0002-6591-9101","position":8,"is_corresponding":false},{"id":1557189,"name":"Qunfang Zhou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Safety profile and cellular uptake of biotemplated nanocapsules with nanometre-thin walls","abstract":"Polymeric nanocapsules with nanometre-thin walls offer a promising platform for controlled cellular delivery of therapeutic or diagnostic agents. Therefore, their biocompatibility is crucial for future applications in the human body. However, there is little knowledge about their interaction with biological systems. In this study, polymeric nanocapsules containing different amounts of lipids and representing different scenarios for handling and storing nanocapsules are investigated. We find that all nanocapsules in our study can enter human cells and the presence of an outer lipid shell facilitates the process. These nanocapsules do not inhibit cell proliferation at concentrations up to 200 μg mL(-1) of nanocapsules. No cellular ROS, apoptosis or cell cycle perturbation is detected at this dose. These comprehensive examinations demonstrate that polymeric nanocapsules are promising nano-carriers for cellular delivery.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21509382","pmcid":null,"openalex_id":"https://openalex.org/W2028887591","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P30CA027165","title":null}],"total_grants":1,"fwci":0.5769,"citation_percentile":0.63541101,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://pubs.rsc.org/en/content/articlepdf/2011/NR/C1NR10311C","host_type":"publisher"},{"url":"https://doi.org/10.1039/c1nr10311c","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21509382","host_type":"repository"}],"fields_of_study":["Nanoparticles: synthesis and applications","RNA Interference and Gene Delivery","Nanoparticle-Based Drug Delivery","Apoptosis","Cell Cycle","Cell Survival","Drug Delivery Systems","Endocytosis","Flow Cytometry","HEK293 Cells","Humans","Jurkat Cells","Lipids","Materials Testing","Microscopy, Electron, Transmission","Nanocapsules","Reactive Oxygen Species"],"mesh_terms":["Cell Cycle","Cell Survival","Endocytosis","Flow Cytometry","Humans","Lipids","Materials Testing","Drug Delivery Systems","Apoptosis","Reactive Oxygen Species","Jurkat Cells","Microscopy, Electron, Transmission","Nanocapsules","HEK293 Cells"],"keywords":["Nanocapsules","Biocompatibility","Nanotechnology","Nanometre","Materials science","Nanoparticle","Biophysics","Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:46:25.023489Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}