{"doi":"10.1039/b806847j","title":"Stable helical peptoids via covalent side chain to side chain cyclization","abstract":null,"journal":"Organic & Biomolecular Chemistry","year":2008,"id":688139,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1029675,"name":"Luc Brunsveld","orcid":"0000-0001-5675-511X","position":1,"is_corresponding":false},{"id":1797696,"name":"Belén Vaz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Stable helical peptoids via covalent side chain to side chain cyclization","abstract":"Peptoids are oligomeric N-substituted glycines with potential as biologically relevant compounds. Helical peptoids provide an attractive fold for the generation of protein-protein interaction inhibitors. The generation of helical peptoid folds in organic and aqueous media has been limited to strict design rules, as peptoid-folding is mainly directed via the steric direction of alpha-chiral side-chains. Here a new methodology is presented to induce helical folds in peptoids with the aid of side chain to side chain cyclization. Cyclic peptoids were generated via solid-phase synthesis and their folding was studied. The cyclization induces significant helicity in peptoids in organic media, aids the folding in aqueous media, and requires the incorporation of only relatively few chiral aromatic side chains.","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18688493","pmcid":null,"openalex_id":"https://openalex.org/W1991597455","authors":[],"funders":[],"total_grants":0,"fwci":1.4305,"citation_percentile":0.7994804,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":4},{"year":2014,"count":1},{"year":2015,"count":4},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://pubs.rsc.org/en/content/articlepdf/2008/OB/B806847J","host_type":"publisher"},{"url":"https://doi.org/10.1039/b806847j","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18688493","host_type":"repository"},{"url":"https://research.tue.nl/en/publications/35dc6e60-3d78-4b37-8d89-8d4415d58b78","host_type":"repository"},{"url":"http://library.tue.nl/csp/dare/LinkToRepository.csp?recordnumber=746212","host_type":"repository"},{"url":"http://edoc.mpg.de/378728","host_type":"repository"},{"url":"http://repository.tue.nl/746212","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-0014-0528-D","host_type":"repository"},{"url":"https://research.tue.nl/nl/publications/35dc6e60-3d78-4b37-8d89-8d4415d58b78","host_type":"repository"}],"fields_of_study":["Chemical Synthesis and Analysis","Biochemical and Structural Characterization","Carbohydrate Chemistry and Synthesis","Circular Dichroism","Cyclization","Molecular Structure","Organic Chemicals","Peptoids","Protein Structure, Secondary","Water"],"mesh_terms":["Circular Dichroism","Cyclization","Organic Chemicals","Water","Molecular Structure","Protein Structure, Secondary","Peptoids"],"keywords":["Peptoid","Side chain","Chemistry","Steric effects","Folding (DSP implementation)","Aqueous medium","Combinatorial chemistry","Stereochemistry","Aqueous solution","Peptide","Organic chemistry","Biochemistry","Polymer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T13:23:23.735559Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}