{"doi":"10.1038/tpj.2014.41","title":"Genetic variation at glucose and insulin trait loci and response to glucose–insulin–potassium (GIK) therapy: the IMMEDIATE trial","abstract":null,"journal":"The Pharmacogenomics Journal","year":2015,"id":608125,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561700,"name":"Y Zhou","orcid":null,"position":1,"is_corresponding":false},{"id":1561701,"name":"J R Beshansky","orcid":null,"position":2,"is_corresponding":false},{"id":1561703,"name":"E Ainehsazan","orcid":null,"position":3,"is_corresponding":false},{"id":164134,"name":"Y Yang","orcid":null,"position":4,"is_corresponding":false},{"id":1561705,"name":"H P Selker","orcid":null,"position":5,"is_corresponding":false},{"id":1561707,"name":"G S Huggins","orcid":null,"position":6,"is_corresponding":false},{"id":1561710,"name":"L A Cupples","orcid":null,"position":7,"is_corresponding":false},{"id":1561713,"name":"I Peter","orcid":null,"position":8,"is_corresponding":false},{"id":1561699,"name":"K L Ellis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Genetic variation at glucose and insulin trait loci and response to glucose–insulin–potassium (GIK) therapy: the IMMEDIATE trial","abstract":"The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are not well understood. We conducted a genetic sub-study of the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care (IMMEDIATE) Trial to explore effects of common and rare glucose and insulin-related genetic loci on initial to 6-h and 6- to 12-h change in plasma glucose and potassium. We identified 27 NOTCH2/ADAM30 and 8 C2CD4B variants conferring a 40-57% increase in glucose during the first 6 h of infusion (P<5.96 × 10(-6)). Significant associations were also found for ABCB11 and SLC30A8 single-nucleotide polymorphisms (SNPs) and glucose responses, and an SEC61A2 SNP with a potassium response to GIK. These studies identify genetic factors that may impact the metabolic response to GIK, which could influence treatment benefits in the setting of acute coronary syndromes (ACS).","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25135348","pmcid":null,"openalex_id":"https://openalex.org/W2042940736","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"1U01HL077826-01","title":"Data Coordinating Center for IMMEDIATE Trial"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL090997-04","title":"Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial"},{"funder_name":"National Institutes of Health","grant_id":"1ZIATR000073-06","title":"A drug-screening platform for autism spectrum disorders using human neurons and astrocytes"},{"funder_name":"National Institutes of Health","grant_id":"3UL1RR025752-02S4","title":"TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCA"},{"funder_name":"National Institutes of Health","grant_id":"5U01HL077821-02","title":"Early EMS and ED Use of GIK for ACS: The IMMEDIATE Trial"},{"funder_name":"National Institutes of Health","grant_id":"1U01HL077823-01","title":"LV Function Assessment Core Lab for IMMEDIATE Trial"}],"total_grants":6,"fwci":0.9957,"citation_percentile":0.75498344,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2020,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"Springer TDM","oa_locations":[{"url":"https://www.nature.com/articles/tpj201441.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/tpj201441.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/tpj201441","host_type":"publisher"},{"url":"https://doi.org/10.1038/tpj.2014.41","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25135348","host_type":"repository"},{"url":"https://research-repository.uwa.edu.au/en/publications/e9cf8acc-fbc5-48e7-a934-2df8bdf225f4","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6512969","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/tpj.2014.41","host_type":""}],"fields_of_study":["Diabetes Treatment and Management","Hyperglycemia and glycemic control in critically ill and hospitalized patients","Heart Failure Treatment and Management","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Double-Blind Method","Female","Glucose","Humans","Insulin","Male","Middle Aged","Potassium","Genetic Variation","Treatment Outcome","Polymorphism, Single Nucleotide","Quantitative Trait Loci","Acute Coronary Syndrome"],"keywords":["Insulin","Single-nucleotide polymorphism","Internal medicine","SNP","Potassium","Endocrinology","Medicine","Biology","Chemistry","Genetics","Genotype","Gene","Adult","Aged, 80 and over","Male","Quantitative Trait Loci","Genetic Variation","Middle Aged","Polymorphism, Single Nucleotide","Glucose","Treatment Outcome","Double-Blind Method","Humans","Female","Acute Coronary Syndrome","Aged"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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