{"doi":"10.1038/srep45684","title":"Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic Ca2+ spike","abstract":"<jats:title>Abstract</jats:title><jats:p>Dendritic Ca<jats:sup>2+</jats:sup>spike endows cortical pyramidal cell with powerful ability of synaptic integration, which is critical for neuronal computation. Here we propose a two-compartment conductance-based model to investigate how the Ca<jats:sup>2+</jats:sup>activity of apical dendrite participates in the action potential (AP) initiation to affect the firing properties of pyramidal neurons. We have shown that the apical input with sufficient intensity triggers a dendritic Ca<jats:sup>2+</jats:sup>spike, which significantly boosts dendritic inputs as it propagates to soma. Such event instantaneously shifts the limit cycle attractor of the neuron and results in a burst of APs, which makes its firing rate reach a plateau steady-state level. Delivering current to two chambers simultaneously increases the level of neuronal excitability and decreases the threshold of input-output relation. Here the back-propagating APs facilitate the initiation of dendritic Ca<jats:sup>2+</jats:sup>spike and evoke BAC firing. These findings indicate that the proposed model is capable of reproducing<jats:italic>in vitro</jats:italic>experimental observations. By determining spike initiating dynamics, we have provided a fundamental link between dendritic Ca<jats:sup>2+</jats:sup>spike and output APs, which could contribute to mechanically interpreting how dendritic Ca<jats:sup>2+</jats:sup>activity participates in the simple computations of pyramidal neuron.</jats:p>","journal":"Scientific Reports","year":2017,"id":658045,"datarank":0.8679759911703766,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.4263101442954104,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.4263101442954104,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":15,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115955,"name":"Jiang Wang","orcid":null,"position":1,"is_corresponding":false},{"id":1717797,"name":"Xile Wei","orcid":null,"position":2,"is_corresponding":false},{"id":1172561,"name":"Bin Deng","orcid":"0000-0002-5590-3755","position":3,"is_corresponding":false},{"id":398203,"name":"Guosheng Yi","orcid":"0000-0002-9362-6605","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic Ca2+ spike","abstract":"<jats:title>Abstract</jats:title><jats:p>Dendritic Ca<jats:sup>2+</jats:sup>spike endows cortical pyramidal cell with powerful ability of synaptic integration, which is critical for neuronal computation. Here we propose a two-compartment conductance-based model to investigate how the Ca<jats:sup>2+</jats:sup>activity of apical dendrite participates in the action potential (AP) initiation to affect the firing properties of pyramidal neurons. We have shown that the apical input with sufficient intensity triggers a dendritic Ca<jats:sup>2+</jats:sup>spike, which significantly boosts dendritic inputs as it propagates to soma. Such event instantaneously shifts the limit cycle attractor of the neuron and results in a burst of APs, which makes its firing rate reach a plateau steady-state level. Delivering current to two chambers simultaneously increases the level of neuronal excitability and decreases the threshold of input-output relation. Here the back-propagating APs facilitate the initiation of dendritic Ca<jats:sup>2+</jats:sup>spike and evoke BAC firing. These findings indicate that the proposed model is capable of reproducing<jats:italic>in vitro</jats:italic>experimental observations. By determining spike initiating dynamics, we have provided a fundamental link between dendritic Ca<jats:sup>2+</jats:sup>spike and output APs, which could contribute to mechanically interpreting how dendritic Ca<jats:sup>2+</jats:sup>activity participates in the simple computations of pyramidal neuron.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28367964","pmcid":"PMC5377381","openalex_id":"https://openalex.org/W2605108107","authors":[],"funders":[],"total_grants":0,"fwci":0.6824,"citation_percentile":0.65711483,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/srep45684.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/srep45684.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/srep45684","host_type":"publisher"},{"url":"http://www.nature.com/doifinder/10.1038/srep45684","host_type":"publisher"},{"url":"https://doi.org/10.1038/srep45684","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28367964","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5377381","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5377381","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5377381?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neural dynamics and brain function","Neuroscience and Neural Engineering","Neuroscience and Neuropharmacology Research","Action Potentials","Algorithms","Animals","Calcium","Calcium Channels","Dendrites","Humans","Ion Channel Gating","Models, Neurological","Pyramidal Cells"],"mesh_terms":["Action Potentials","Algorithms","Animals","Calcium","Dendrites","Humans","Models, Neurological","Calcium Channels","Ion Channel Gating","Pyramidal Cells"],"keywords":["Dendritic spike","Soma","Dendrite (mathematics)","Neuroscience","Bursting","Spike (software development)","Neuron","Compartment (ship)","Electrophysiology","Biological neuron model","Apical dendrite","Biophysics","Biology","Physics","Chemistry","Inhibitory postsynaptic potential","Computer science","Excitatory postsynaptic potential","Mathematics","Geometry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T03:08:11.671475Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}