{"doi":"10.1038/srep21505","title":"Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells","abstract":"<jats:title>Abstract</jats:title><jats:p>Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult lifespan of mammals, they progressively exhibit proliferation defects that contribute to a sharp reduction in subventricular neurogenesis during aging. However, little is known regarding the early age-related events in neurogenic niches. Using a fluorescence-activated cell sorting technique that allows for the prospective purification of the main neurogenic populations from the subventricular zone (SVZ), we demonstrated an early decline in adult neurogenesis with a dramatic loss of progenitor cells in 4 month-old young adult mice. Whereas the activated and quiescent NSC pools remained stable up to 12 months, the proliferative status of activated NSCs was already altered by 6 months, with an overall extension of the cell cycle resulting from a specific lengthening of G<jats:sub>1</jats:sub>. Whole genome analysis of activated NSCs from 2- and 6-month-old mice further revealed distinct transcriptomic and molecular signatures, as well as a modulation of the TGFβ signalling pathway. Our microarray study constitutes a cogent identification of new molecular players and signalling pathways regulating adult neurogenesis and its early modifications.</jats:p>","journal":"Scientific Reports","year":2016,"id":20230,"datarank":3.134382872921174,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"self_citation_contribution":0.6782682865573562,"citation_network_contribution":2.456114586363818,"self_endowment_contribution":0.6782682865573562,"citer_contribution":2.456114586363818,"corpus_percentile":null,"corpus_rank":null,"citation_count":91,"citer_count":76,"citers_with_citation_signal":72,"citers_with_endowment":72,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":134465,"name":"Lise Morizur","orcid":null,"position":1,"is_corresponding":false},{"id":134466,"name":"Alexandra Chicheportiche","orcid":null,"position":2,"is_corresponding":false},{"id":134467,"name":"Marc-André Mouthon","orcid":null,"position":3,"is_corresponding":false},{"id":134468,"name":"François D. Boussin","orcid":null,"position":4,"is_corresponding":false},{"id":134464,"name":"Mathieu Daynac","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26893147","pmcid":"PMC4759590","openalex_id":"https://openalex.org/W2409842303","authors":[],"funders":[],"total_grants":0,"fwci":6.5927,"citation_percentile":0.97777316,"influential_citations":2,"citation_trend":[{"year":2016,"count":1},{"year":2017,"count":12},{"year":2018,"count":9},{"year":2019,"count":12},{"year":2020,"count":23},{"year":2021,"count":8},{"year":2022,"count":4},{"year":2023,"count":14},{"year":2024,"count":2},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.nature.com/articles/srep21505.pdf","host_type":"journal"},{"url":"https://www.nature.com/articles/srep21505.pdf","host_type":"GOLD"},{"url":"https://www.nature.com/articles/srep21505.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/srep21505","host_type":"publisher"},{"url":"https://doi.org/10.1038/srep21505","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26893147","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4759590","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4759590","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4759590?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Epigenetics and DNA Methylation","MicroRNA in disease regulation","Biology","Medicine","Age Factors","Aging","Animals","Biomarkers","Cell Count","Cell Cycle","Cluster Analysis","Computational Biology","Gene Expression Profiling","Lateral Ventricles","Mice","Mice, Transgenic","Neural Stem Cells","Neurogenesis"],"mesh_terms":["Age Factors","Aging","Animals","Cell Count","Cell Cycle","Mice, Transgenic","Biomarkers","Cluster Analysis","Computational Biology","Lateral Ventricles","Gene Expression Profiling","Mice","Neurogenesis","Neural Stem Cells"],"keywords":["Neurogenesis","Subventricular zone","Neural stem cell","Biology","Stem cell","Progenitor cell","Transcriptome","Cell biology","Progenitor","Neuroscience","Gene expression","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.11999391.v1","title":"Additional file 1 of Lrig1 expression prospectively 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