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Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger “co-aging” than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.</jats:p>","journal":"Scientific Reports","year":2016,"id":6810,"datarank":10.448830651679677,"base_score":6.583409222158765,"endowment":6.583409222158765,"self_citation_contribution":0.9875113833238148,"citation_network_contribution":9.461319268355862,"self_endowment_contribution":0.9875113833238148,"citer_contribution":9.461319268355862,"corpus_percentile":null,"corpus_rank":null,"citation_count":722,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.3501,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2016-01-21","algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32788,"name":"Tao Huang","orcid":"0000-0002-1337-8403","position":1,"is_corresponding":false},{"id":49516,"name":"Francesca Petralia","orcid":"0000-0001-5096-9854","position":2,"is_corresponding":false},{"id":27519,"name":"Quan Long","orcid":"0000-0003-3795-1873","position":3,"is_corresponding":false},{"id":4392,"name":"Bin Zhang","orcid":"0000-0002-4579-1075","position":4,"is_corresponding":false},{"id":5805,"name":"Carmen Argmann","orcid":"0000-0002-1110-8012","position":5,"is_corresponding":false},{"id":27778,"name":"Yong Zhao","orcid":"0000-0001-9290-109X","position":6,"is_corresponding":false},{"id":49517,"name":"Charles V. 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