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We also designed Bcl-xL mutants which cannot dimerize and show that these mutants reduced mitochondrial calcium uptake in MEF cells. This illustrates the structural plasticity in Bcl-xL providing hints toward the probable molecular mechanism for Bcl-xL to play a regulatory role in mitochondrial calcium ion transport.</jats:p>","journal":"Scientific Reports","year":2015,"id":589983,"datarank":1.2339928105822735,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.7452783298790511,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.7452783298790511,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":22,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1509542,"name":"Minjoo Choi","orcid":null,"position":1,"is_corresponding":false},{"id":1509543,"name":"Quoc Toan Nguyen","orcid":null,"position":2,"is_corresponding":false},{"id":819301,"name":"Hong Ye","orcid":"0000-0003-0232-9013","position":3,"is_corresponding":false},{"id":719750,"name":"Wei Liu","orcid":"0000-0001-6739-9990","position":4,"is_corresponding":false},{"id":290613,"name":"Hui Ting Toh","orcid":null,"position":5,"is_corresponding":false},{"id":289842,"name":"CongBao Kang","orcid":"0000-0002-9886-9374","position":6,"is_corresponding":false},{"id":1509544,"name":"Neelagandan Kamariah","orcid":null,"position":7,"is_corresponding":false},{"id":478843,"name":"Chi Li","orcid":"0000-0001-8588-2898","position":8,"is_corresponding":false},{"id":420122,"name":"Huiya Huang","orcid":"0000-0002-1773-9915","position":9,"is_corresponding":false},{"id":1002294,"name":"Carl White","orcid":"0000-0002-0535-6968","position":10,"is_corresponding":false},{"id":1509545,"name":"Kwanghee Baek","orcid":null,"position":11,"is_corresponding":false},{"id":270340,"name":"Gerhard Grüber","orcid":"0000-0002-5730-8319","position":12,"is_corresponding":false},{"id":289850,"name":"Ho Sup Yoon","orcid":"0000-0002-8243-3904","position":13,"is_corresponding":false},{"id":1509541,"name":"Sreekanth Rajan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport","abstract":"<jats:title>Abstract</jats:title><jats:p>Bcl-2 family proteins are key regulators for cellular homeostasis in response to apoptotic stimuli. 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