{"doi":"10.1038/sj.onc.1207556","title":"Mitogen-activated protein kinases in apoptosis regulation","abstract":null,"journal":"Oncogene","year":2004,"id":598072,"datarank":1.0906512807421491,"base_score":7.271008538280992,"endowment":7.271008538280992,"self_citation_contribution":1.0906512807421491,"citation_network_contribution":0.0,"self_endowment_contribution":1.0906512807421491,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1437,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1532344,"name":"Josef M Penninger","orcid":null,"position":1,"is_corresponding":false},{"id":1532343,"name":"Teiji Wada","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mitogen-activated protein kinases in apoptosis regulation","abstract":"Cells are continuously exposed to a variety of environmental stresses and have to decide 'to be or not to be' depending on the types and strength of stress. Among the many signaling pathways that respond to stress, mitogen-activated protein kinase (MAPK) family members are crucial for the maintenance of cells. Three subfamilies of MAPKs have been identified: extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38-MAPKs. It has been originally shown that ERKs are important for cell survival, whereas JNKs and p38-MAPKs were deemed stress responsive and thus involved in apoptosis. However, the regulation of apoptosis by MAPKs is more complex than initially thought and often controversial. In this review, we discuss MAPKs in apoptosis regulation with attention to mouse genetic models and critically point out the multiple roles of 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and MAPK Pathways","Protein Kinase Regulation and GTPase Signaling","Cell death mechanisms and regulation","Animals","Apoptosis","Humans","MAP Kinase Signaling System","Mitogen-Activated Protein Kinase 8","Mitogen-Activated Protein Kinase 9","Mitogen-Activated Protein Kinases","Neoplasms","p38 Mitogen-Activated Protein Kinases"],"mesh_terms":["Animals","Humans","Neoplasms","Apoptosis","Mitogen-Activated Protein Kinases","MAP Kinase Signaling System","p38 Mitogen-Activated Protein Kinases","Mitogen-Activated Protein Kinase 8","Mitogen-Activated Protein Kinase 9"],"keywords":["p38 mitogen-activated protein kinases","Kinase","Biology","Mitogen-activated protein kinase","MAPK/ERK pathway","Cell biology","Signal transduction","Apoptosis","ASK1","Protein kinase A","Mitogen-activated protein kinase kinase","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12680053.v1","title":"Additional file 1 of EO771, the first 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