{"doi":"10.1038/sj.onc.1206679","title":"Regulation and mechanisms of mammalian double-strand break repair","abstract":null,"journal":"Oncogene","year":2003,"id":627498,"datarank":0.950258137724709,"base_score":6.335054251498059,"endowment":6.335054251498059,"self_citation_contribution":0.950258137724709,"citation_network_contribution":0.0,"self_endowment_contribution":0.950258137724709,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":563,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1624119,"name":"Lawrence F Povirk","orcid":null,"position":1,"is_corresponding":false},{"id":117104,"name":"Kristoffer Valerie","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulation and mechanisms of mammalian double-strand break repair","abstract":"The double-strand break (DSB) is believed to be one of the most severe types of DNA damage, and if left unrepaired is lethal to the cell. Several different types of repair act on the DSB. The most important in mammalian cells are nonhomologous end-joining (NHEJ) and homologous recombination repair (HRR). NHEJ is the predominant type of DSB repair in mammalian cells, as opposed to lower eucaryotes, but HRR has recently been implicated in critical cell signaling and regulatory functions that are essential for cell viability. Whereas NHEJ repair appears constitutive, HRR is regulated by the cell cycle and inducible signal transduction pathways. More is known about the molecular details of NHEJ than HRR in mammalian cells. This review focuses on the mechanisms and regulation of DSB repair in mammalian cells, the signaling pathways that regulate these processes and the potential crosstalk between NHEJ and HRR, and between repair and other stress-induced pathways with emphasis on the regulatory circuitry associated with the ataxia telangiectasia mutated (ATM) protein.","is_dataset_classified":null,"base_score":6.335054251498059,"endowment":6.335054251498059,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12947387","pmcid":null,"openalex_id":"https://openalex.org/W2169637630","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA40615","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01CA72955","title":null},{"funder_name":"National Institutes of Health","grant_id":"1P01CA072955-01A1","title":"GENETIC MODULATION OF CELLULAR RADIATION RESPONSES"}],"total_grants":3,"fwci":16.2742,"citation_percentile":0.99612495,"influential_citations":0,"citation_trend":[{"year":2012,"count":33},{"year":2013,"count":22},{"year":2014,"count":16},{"year":2015,"count":30},{"year":2016,"count":10},{"year":2017,"count":14},{"year":2018,"count":15},{"year":2019,"count":12},{"year":2020,"count":18},{"year":2021,"count":9},{"year":2022,"count":12},{"year":2023,"count":8},{"year":2024,"count":6},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"closed","license":"Springer TDM","oa_locations":[{"url":"https://www.nature.com/articles/1206679.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/1206679","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.onc.1206679","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12947387","host_type":"repository"},{"url":"https://dx.doi.org/10.1038/sj.onc.1206679","host_type":""}],"fields_of_study":["DNA Repair Mechanisms","Cancer-related Molecular Pathways","Microtubule and mitosis dynamics","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","DNA Damage","DNA Repair","Free Radicals","Humans","X-Rays","Signal Transduction","Apoptosis"],"keywords":["Biology","DNA repair","Non-homologous end joining","Cell biology","Crosstalk","Homologous recombination","Ku80","DNA damage","Cell cycle","DNA repair protein XRCC4","Signal transduction","Homology directed repair","Genetics","Cell","DNA","Nucleotide excision repair","DNA-binding protein","Transcription factor","Gene","Free Radicals","X-Rays","Animals","Humans","Apoptosis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T17:46:12.875215Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}