{"doi":"10.1038/sj.onc.1204198","title":"Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I","abstract":null,"journal":"Oncogene","year":2001,"id":609118,"datarank":0.6476232170304466,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":0.0,"self_endowment_contribution":0.6476232170304466,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1516000,"name":"Kiyoshi Ohtani","orcid":null,"position":1,"is_corresponding":false},{"id":1174686,"name":"Ritsuko Iwanaga","orcid":"0009-0008-1142-4753","position":2,"is_corresponding":false},{"id":1565431,"name":"Yuuki Matsumura","orcid":null,"position":3,"is_corresponding":false},{"id":1301630,"name":"Masataka Nakamura","orcid":"0000-0002-0439-5682","position":4,"is_corresponding":false},{"id":1565430,"name":"Yongping Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I","abstract":"Cyclins are one of the pivotal determinants regulating cell cycle progression. We previously reported that the trans-activator Tax of human T-cell leukemia virus type I (HTLV-I) induces endogenous cyclin D2 expression along with cell cycle progression in a resting human T-cell line, Kit 225, suggesting a role of cyclin D2 in Tax-mediated cell cycle progression. The cyclin D2 gene has a typical E2F binding element, raising the possibility that induction of cyclin D2 expression is a consequence of cell cycle progression. In this study, we examined the role and molecular mechanism of induction of the endogenous human cyclin D2 gene by Tax. Introduction of p19(INK4d), a cyclin dependent kinase (CDK) inhibitor of the INK4 family specific for D-type CDK, inhibited Tax-mediated activation of E2F, indicating requirement of D-type CDK in Tax-mediated activation of E2F. Previously indicated E2F binding element and two NF-kappaB-like binding elements in the 1.6 kbp cyclin D2 promoter fragment had little, if any, effect on responsiveness to Tax. We found that trans-activation of the cyclin D2 promoter by Tax was mainly mediated by a newly identified NF-kappaB-like element with auxiliary contribution of a CRE-like element residing in sequences downstream of -444 which were by themselves sufficient for trans-activation by Tax. These results indicate that Tax directly trans-activates the cyclin D2 gene, resulting in growth promotion and perhaps leukemogenesis through activation of D-type CDK.","is_dataset_classified":null,"base_score":4.31748811353631,"endowment":4.31748811353631,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11314046","pmcid":null,"openalex_id":"https://openalex.org/W1994486114","authors":[],"funders":[],"total_grants":0,"fwci":1.772,"citation_percentile":0.84629169,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2024,"count":3},{"year":2025,"count":2}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/1204198.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/1204198","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.onc.1204198","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11314046","host_type":"repository"}],"fields_of_study":["T-cell and Retrovirus Studies","Vector-Borne Animal Diseases","Animal Disease Management and Epidemiology"],"mesh_terms":["Carrier Proteins","Cell Line","DNA-Binding Proteins","Electrophoresis, Agar Gel","Humans","Luciferases","Promoter Regions, Genetic","Transcription Factors","Human T-lymphotropic virus 1","Chloramphenicol O-Acetyltransferase","Transcriptional Activation","Cyclins","NF-kappa B","Gene Products, tax","Gene Deletion","Cyclic AMP Response Element-Binding Protein","DNA Primers","Cell Cycle Proteins","Cyclin-Dependent Kinases","Jurkat Cells","Transcription Factor DP1","E2F Transcription Factors","Retinoblastoma-Binding Protein 1","Cyclin D2"],"keywords":["Cyclin-dependent kinase","Cyclin A2","Cyclin D","Biology","Cyclin D2","Cyclin A","Cyclin B","Cancer research","E2F","Cyclin E","Cell cycle","Cyclin","Cyclin D1","Cell biology","Molecular biology","Genetics","Cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T03:26:16.517662Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}