{"doi":"10.1038/sj.onc.1201046","title":"Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity","abstract":null,"journal":"Oncogene","year":1997,"id":637466,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1655234,"name":"Kim E Boulukos","orcid":null,"position":1,"is_corresponding":false},{"id":1655236,"name":"Christel Aperlo","orcid":null,"position":2,"is_corresponding":false},{"id":141982,"name":"Mitsuaki Fujimoto","orcid":null,"position":3,"is_corresponding":false},{"id":1655238,"name":"Hiroyoshi Ariga","orcid":null,"position":4,"is_corresponding":false},{"id":138363,"name":"Akio Nomoto","orcid":null,"position":5,"is_corresponding":false},{"id":87242,"name":"Hiroyuki Kato","orcid":"0000-0002-4996-632X","position":6,"is_corresponding":false},{"id":1655233,"name":"Philippe Pognonec","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity","abstract":"Heterodimerization among the basic-leucine zipper (bZIP) proteins or among the basic-helix-loop-helix-leucine zipper (bHLHZip) proteins confers a multitude of combinational activities to these transcription factors. To further examine the function of the bHLHZip protein, USF, we screened for cellular proteins which could directly interact with USF using the yeast two-hybrid system. A bZip protein, Fra1, was found to efficiently interact with USF. USF specifically interacts with Fra1 but not with other closely related family members, c-Fos, Fra2, FosB, or with c-Jun. Both the bHLHZip and the N-terminal regions of Fra1 are required for efficient interaction with USF. In vivo association between USF and Fra1 has been demonstrated by co-immunoprecipitation. Expression of exogenous USF led to a decrease in AP1-dependent transcription in F9 cells. Co-expression of exogenous Fra1 restored the AP1 activity in a dose-dependent manner. These data show that USF and Fra1 physically and functionally interact demonstrating that cross-talk occurs between factors of distantly related transcription families.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9160889","pmcid":null,"openalex_id":"https://openalex.org/W2329831854","authors":[],"funders":[],"total_grants":0,"fwci":2.0093,"citation_percentile":0.87637097,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2021,"count":2},{"year":2022,"count":2}],"oa_status":"closed","license":"https://www.springer.com/tdm","oa_locations":[{"url":"https://www.nature.com/articles/1201046.pdf","host_type":"publisher"},{"url":"https://www.nature.com/articles/1201046","host_type":"publisher"},{"url":"https://doi.org/10.1038/sj.onc.1201046","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9160889","host_type":"repository"}],"fields_of_study":["Fungal and yeast genetics research","Plant Molecular Biology Research","Plant Reproductive Biology","Animals","DNA-Binding Proteins","Dimerization","Genes, Reporter","Helix-Loop-Helix Motifs","Humans","Leucine Zippers","Mice","Protein Binding","Proto-Oncogene Proteins c-fos","Rabbits","Recombinant Fusion Proteins","Saccharomyces cerevisiae","Transcription Factor AP-1","Transcription Factors","Transcription, Genetic","Upstream Stimulatory Factors","beta-Galactosidase","Fos-Related Antigen 1"],"mesh_terms":["Fos-Related Antigen 1","Animals","beta-Galactosidase","DNA-Binding Proteins","Humans","Protein Binding","Rabbits","Recombinant Fusion Proteins","Saccharomyces cerevisiae","Transcription Factors","Transcription, Genetic","Leucine Zippers","Proto-Oncogene Proteins c-fos","Genes, Reporter","Helix-Loop-Helix Motifs","Transcription Factor AP-1","Dimerization","Mice","Upstream Stimulatory Factors"],"keywords":["Leucine zipper","Biology","AP-1 transcription factor","Transcription factor","bZIP domain","FOSB","Transcription (linguistics)","Cell biology","Genetics","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:59:24.160308Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}